五经配伍调气法针刺治疗肝胃不和型胃食管反流病的临床观察  

Clinical Observation of Five Meridians Compatibility to Regulate Qi Acupuncture in Treating Gastroesophageal Reflux Disease of Liver-Stomach Disharmony Type

作　　者：王雪娇 孙光 于翔[1] 黄磊[3] 潘鸿 WANG Xue-Jiao;SUN Guang;YU Xiang;HUANG Lei;PAN Hong(Dept.of Acupuncture and Moxibustion,Beijing Changping District Integrated Traditional Chinese and Western Medicine Hospital,Peking 102208,China;Experimental Center of Jilin Provincial Hospital of Traditional Chinese Medicine,Changchun 130021 Jilin,China;Dept.of Orthopaedics,Beijing Changping District Integrated Traditional Chinese and Western Medicine Hospital,Peking 102208,China;Dept.of Pediatrics,Beijing Haidian District Hospital of Traditional Chinese Medicine,Peking 100086,China)

机构地区：[1]北京市昌平区中西医结合医院针灸科,北京102208 [2]吉林省中医院实验中心,吉林长春130021 [3]北京市昌平区中西医结合医院骨伤科,北京102208 [4]北京市海淀区中医医院儿科,北京100086

出　　处：《广州中医药大学学报》2020年第10期1924-1929,共6页Journal of Guangzhou University of Traditional Chinese Medicine

摘　　要：【目的】观察五经配伍调气法针刺治疗肝胃不和型胃食管反流病的临床疗效。【方法】将138例肝胃不和型胃食管反流病患者随机分为西药组、针刺组和联合组,每组各46例。西药组给予多潘立酮胶囊10 mg,每日3次口服,连续治疗14 d;针刺组根据五经配伍调气法,取期门、内关、中脘、天枢、太冲、足三里、行间穴进行针刺;联合组在西药组治疗的基础上,同时联合针刺组的治疗方案进行治疗。治疗14 d后,观察3组患者治疗前后血清饥饿激素(Ghrelin)、血管活性肽(VIP)的变化情况,以及肿瘤坏死因子α(TNF-α)、白细胞介素8(IL-8)的水平,并评价3组的临床疗效。【结果】(1)治疗后,3组患者的Ghrelin、VIP含量均明显改善(P<0.05),且联合组在改善Ghrelin、VIP含量方面均明显优于西药组与针刺组,差异有统计学意义(P<0.05)。(2)治疗后,3组患者的IL-8、TNF-α含量均明显改善(P<0.05),且联合组在改善IL-8、TNF-α含量方面均明显优于西药组与针刺组,差异有统计学意义(P<0.05)。(3)西药组总有效率为93.49%(43/46),针刺组为91.30%(42/46),联合组为97.83%(45/46)。联合组疗效优于针刺组和西药组,差异有统计学意义(P<0.05)。【结论】五经配伍调气法针刺治疗肝胃不和型胃食管反流病,能明显改善患者的临床症状和炎症状态,疗效显著。Objective To observe the clinical efficacy of five meridians compatibility to regulate qi acupuncture for the treatment gastroesophageal reflux disease of liver-stomach disharmony type. Methods One-hundred and thirtyeight patients with gastroesophageal reflux disease of liver-stomach disharmony type were randomly divided into western medicine group,acupuncture group,combination group,46 cases in each group. The western medicine group received oral use of penlidone capsules of 10 mg, 3 times per day, for 14 continuous days, the acupuncture group received five meridians compatibility to regulate qi acupuncture at Qimen(LR14),Neiguan(PC6),Zhongwan(CV12),Tianshu(ST25),Taichong(LR3),Zusanli(ST36),Xingjian(LR2)points,and the combination group received the combination of the treatment of western medicine group and acupuncture group.After 14 days of treatment, the changes in serum Ghrelin, vasoactive intestinal polypeptide(VIP), tumor necrosis factor α(TNF-α),and interleukin 8(IL-8)were observed in the 3 groups,and the clinical effect was evaluated in the 3 groups. Results(1)After treatment, the contents of Ghrelin and VIP in the 3 groups were significantly improved(P<0.05),and the improvement in contents of Ghrelin and VIP of the combination group was significantly superior to that of the western medicine group and acupuncture group(P<0.05).(2)After treatment,the contents of IL-8 and TNF-α in the 3 groups were significantly improved(P<0.05),and the improvement in contents of IL-8 and TNF-α of the combination group was significantly superior to that of the western medicine group and acupuncture group(P<0.05).(3)The total effective rate was 93.49%(43/46)in the western medicine group, 91.30%(42/46)in the acupuncture group, and 97.83%(45/46)in the combination group. The therapeutic effect in the combination group was significantly superior to that of the western medicine group and acupuncture group(P<0.05). Conclusion Five meridians compatibility to regulate qi acupuncture is effective for improving clinical symptoms an

关 键 词：五经配伍调气法 针刺 食管反流病 五行生克制化理论 

分 类 号：R246.9[医药卫生—针灸推拿学]