干细胞诱导分化为视网膜色素上皮细胞的途径探讨  

Approach discussion of the differentiation of stem cells induced to retinal pigment epithelial cells

作　　者：陈瑾[1] 徐国兴[1] Jin Chen;Guo-Xing Xu(Fujian Institute of Ophthalmology, Department of Ophthalmology, the First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, Fujian Province, China)

机构地区：[1]福建医科大学附属第一医院眼科福建省眼科研究所,中国福建省福州市350005

出　　处：《国际眼科杂志》2020年第10期1722-1725,共4页International Eye Science

基　　金：国家自然科学基金资助项目(No.81770948);福建省科技创新领军人才基金资助项目(No.2016B011)。

摘　　要：近年来,干细胞在眼科领域的研究及应用受到高度关注,胚胎干细胞(ES)、成体干细胞能够被定向诱导分化成视网膜色素上皮细胞,由此可获得转分化的大量的视网膜色素上皮细胞源,通过体内干细胞及视网膜色素上皮细胞移植有望应用于各种视网膜退行性疾病的细胞替代治疗。本文就各种干细胞诱导分化为视网膜色素上皮细胞的途径及应用进行探讨。In recent years,stem cell research and application in the field of ophthalmology has been highlighted,embryonic stem cells and adult stem cells can be targeted induced to differentiate into retinal pigment epithelial cells(RPE cells),which can obtain transdifferentiation of RPE cells source,through the body stem cells and retinal pigment epithelium cells transplantation is expected to be used in a variety of alternative treatment of the degenerative diseases of the retina.In this paper,the methods and application of various stem cells induced differentiation into RPE cells were discussed.

关 键 词：干细胞 诱导分化 视网膜色素上皮细胞 

分 类 号：R32[医药卫生—人体解剖和组织胚胎学]