成人眼弓蛔虫病的临床特征分析  

Clinical characteristics of ocular toxocariasis in adults

作　　者：孙立梅[1] 李松珊 曹丽明 王韦清 丁小燕[1] Sun Limei;Li Songshan;Cao Liming;Wang Weiqing;Ding Xiaoyan(Department of pediatric ophthalmology,State Key Laboratory of Ophthalmology,Zhongshan Ophthalmic Center,Sun Yat-sen University,Guangzhou 510060,China)

机构地区：[1]中山大学中山眼科中心眼科学国家重点实验室,广州510060

出　　处：《中华眼底病杂志》2020年第9期685-690,共6页Chinese Journal of Ocular Fundus Diseases

摘　　要：目的观察成人眼弓蛔虫病(OT)患者临床特征。方法回顾性临床研究。2017年1月至2019年12月于中山大学中山眼科中心检查确诊的连续OT患者83例中,年龄≥18岁者14例(16.9%,成人组)纳入研究。选取2019年7~12月连续就诊的年龄<18岁的OT患者14例(儿童组)作为对照。患者均行BCVA、裂隙灯显微镜、眼底彩色照相、B型超声检查。行UBM检查18例,其中成人组、儿童组分别为6、12例;行FFA检查23例,其中成人组、儿童组分别为12、11例。BCVA检查采用Snellen视力表进行,统计时换算为logMAR视力。对比观察两组患者居住地(城镇或农村)、犬猫接触史、主要症状、就诊原因、病程以及临床和影像学特点等。符合正态分布的计量资料,组间比较行t检验;偏态分布计量资料,组间比较行秩和检验。结果成年组、儿童组患者犬猫接触史(Z=2.661)、首诊至确诊时间(t=-0.186)比较,差异无统计学意义(P=0.257、0.351);与儿童组比较,成人组患者居住环境主要为城镇,病程明显较短(Z=-2.005),差异有统计学意义(P=0.047)。成人组、儿童组患者首诊时logMAR BCVA分别为0.81±1.08、2.08±1.30,差异有统计学意义(Z=-2.811,P=0.004);与儿童组比较,成人组患者玻璃体混浊程度更轻,差异有统计学意义(Z=7.847,P=0.048)。FFA检查,视网膜毛细血管"羊齿蕨样"渗漏20例。其中,成人组、儿童组分别为10(83.3%,10/12)、10(90.9%,10/11)例。结论OT患者中成人患者占16.9%;与儿童患者比较,成人患者多居住于城镇或城市,病程短,初诊时视力好,玻璃体腔炎症或增生轻微;FFA有助于成人OT诊断。Objective To observe the clinical characteristics of adult patients with ocular toxoplasmosis(OT).Methods This study was a retrospective clinical trial.Among the 83 consecutive OT patients diagnosed in the Zhongshan Eye Center of Sun Yat-Sen University,14 patients(16.9%,adult group)aged≥18 years were included in the study from January 2017 to December 2019.A total of 14 OT patients(children group)aged less than 18 years who had consecutive visits from July to December 2019 were selected as controls.All patients underwent BCVA,slit lamp microscope,fundus color photography,and B-mode ultrasound examination.Eighteen cases underwent UBM examination,including 6 and 12 cases in the adult group and child group respectively;23 cases underwent FFA examination,including 12 and 11 cases in the adult group and child group respectively.Snellen visual acuity chart was used for BCVA examination,which was converted into logMAR visual acuity in statistics.We compared the two groups of patients'residence(urban or rural),history of contact with dogs and cats,main symptoms,reasons for treatment,course of disease,and clinical and imaging characteristics and so on.For measurement data conforming to normal distribution,t-test was performed for comparison between groups;for Skewness distribution measurement data,rank sum test was performed for comparison between groups.Results Compared with the adult group and the child group,there was no significant difference in the canine-cat contact history(Z=2.661,P=0.257)and the time from first diagnosis to diagnosis(t=-0.186,P=0.351);compared with the children group and the adult group,the patient's living environment was mainly urban,and the course of disease was significantly shorter(Z=-2.005),and the difference was statistically significant(P=0.047).The logMAR BCVA of the adult group and the child group were 0.81±1.08 and 2.08±1.30,respectively,and the difference was statistically significant(Z=-2.811,P=0.004);compared with the child group,the adult group had lighter vitreous opacities,but

关 键 词：弓形虫病 眼/诊断 成年人 疾病特征 

分 类 号：R532.11[医药卫生—内科学] R771.3[医药卫生—临床医学]