经导管封堵治疗卵圆孔未闭合并不明原因偏头痛的效果与近期随访观察  

The therapeutic effect by catheterization on different types of patent foramen ovale with unidentified migrain and its short-term follow-up

作　　者：杭永斌 唐跃 李波[1] 孙子瑞 刘煜昊 HANG Yong-bin;TANG Yue;LI Bo;SUN Zi-rui;LIU Yu-hao(Cardiovascular Center,The Seventh Affiliated Hospital,Sun Yat-sen University,Shenzheng 518000,China;Structural Heart Disease Ward,Fuwai Central China cardiovascular Hospital,Zhengzhou 450000,China)

机构地区：[1]中山大学附属第七医院心血管中心,广东省深圳市581000 [2]阜外华中心血管病医院结构性心脏病病区

出　　处：《中国心血管病研究》2020年第9期814-818,共5页Chinese Journal of Cardiovascular Research

摘　　要：目的研究不同类型卵圆孔未闭合并不明原因偏头痛经导管封堵治疗效果并进行近期随访观察.方法回顾性分析2016年12月至2019年12月来我院进行治疗的127例不同类型卵圆孔未闭合并不明原因偏头痛患者,依据最终卵圆孔未闭合并不明原因偏头痛经导管封堵的类型分为简单型组(79例)与复杂型组(48例),比较两组患者一般生理指标和头痛特征,随访1年观察各时间段两组患者的头痛缓解情况.结果简单型组与复杂型组在治疗1个月后的HIT-6评分分别为(59.73±7.13)分、(62.74±3.34)分,与治疗前相较差异均无统计学意义(t=4.846,P=0.065;t=3.457,P=0.090);简单型组与复杂型组在治疗1个月后的头痛发作频次分别为(4.11±1.42)次、(4.43±1.22)次,与治疗前相较差异均无统计学意义(t=5.235,P=0.060;t=5.883,P=0.054).在进行治疗3个月后比较简单型组与复杂型组治疗前后HIT-6评分分别为(44.83±4.72)分、(61.79±3.91)分,头痛发生频次分别为(2.21±1.02)次、(3.83±1.31)次,简单型组治疗后的HIT-6评分显著性低于治疗前、复杂型组治疗后(t=21.832,P=0.015;t=15.324,P=0.021),简单型组治疗后的头痛发作频次显著性低于治疗前、复杂型组治疗后(t=19.736,P=0.016;t=15.992,P=0.020);在进行治疗6个月后比较简单型组与复杂型组治疗前后HIT-6评分分别为(35.13±2.52)分、(42.57±3.49)分,头痛发生频次分别为(1.85±1.02)次、(2.31±4.72)次,简单型组治疗后的HIT-6评分显著性低于治疗前、复杂型组治疗后(t=24.587,P=0.013;t=14.234,P=0.022).结论不同类型卵圆孔未闭合并偏头痛患者在进行经导管封堵治疗后,复杂型卵圆孔未闭与简单型卵圆孔未闭均表现出良好的治疗效果,但是复杂型卵圆孔未闭,解剖结构较为复杂,封堵器偏大,完全内皮化所需时间较长,导致改善效果迟显.Objective To study the therapeutic effect of different types of patent foramen ovale(PFO)with unidentified migraine cloesd by catheterization and follow-up in the near future.Methods Retrospective analysis of 127 cases of diferent types of PFP that were trated in our hospital between December 2016 and December 2019 combined with unexplained migraines.According to the type of final PFO with unidentified migrain by transcatheter closure was divided into simple type group(79 cases)and complexity(48 cases)and compare two groups of patients with general physiological indexes and characteristics of headache and follow-up observation.Results The HIT-6 scores of simple type group and complex type group were(59.73±7.13)points and(62.74±3.34)points respectively after I month of treatment and there was no significant difference compared with those before treatment(1=4.846.P=0.065;1=3.457.P=0.090);the frequency of headache attack in simple type group and complex type group after 1 month of treatment were(4.11±1.42)times and(4.43±1.22)times,respectively,compared with those before treatment,there was no statistical significance(1-5.235.P=0.060;1=5.883,P=0.054).After 3 months of treatment.the HIT-6 scores of simple type group and complex type group were(44.83±4.72)points and(61.79±3.91)points respectively and the frequency of headache was(2.21±1.02)times and(3.83±1.31)times respectively.The HIT-6 score of simple type group after treatment was significantly lower than that before treatment and after treatment in complex type group(1=21.832.P=0.015;1=15.324,P=0.021).The frequency of headache attack after treatment was significantly lower than that before treatment and after treatment in complex type group(1=19.736.P=0.016;1=15.992.P=0.020);after 6 months of treatment.,HIT-6 scores of simple type group and complex type group were(35.13±2.52)points and(42.57±3.49)points before and after treatment and the occurrence frequency of headache in simple type group was(1.85±1.02)times and(2.31±4.72)times respectively HIT-6 scor

关 键 词：卵圆孔未闭 偏头痛 随访观察 经导管封堵 

分 类 号：R654.2[医药卫生—外科学]