广州市同德围地区女性生殖道支原体感染的药敏分析  

Drug sensitivity analysis on mycoplasma infection of female genital tract in Tongdewei region of Guangzhou City

作　　者：梁涯 卫丽[2] 李秋明 周伟青 刘道利 高东华 曾亭亭 陈柯艺 Liang Ya;Wei Li;Li Qiuming;Zhou Weiqing;Liu Daoli;Gao Donghua;Zeng Tingting;Chen Keyi(Clinical Laboratory,the Affiliated Traditional Chinese Medicine Hospital of Guangzhou Medical University,Guangzhou 511400,Guangdong,China;Clinical Laboratory,Qinghai Provincial People's Hospital,Xining 810000,Qinghai,China;Medical Genetics Center,Guangdong Provincial Women and Children Hospital,Guangzhou 511442,Guangdong,China)

机构地区：[1]广州医科大学附属中医医院检验科,广东广州511400 [2]青海省人民医院医学检验科,青海西宁810000 [3]广东省妇幼保健院医学遗传中心,广东广州511442

出　　处：《实用检验医师杂志》2020年第3期162-165,共4页Chinese Journal of Clinical Pathologist

摘　　要：目的分析广州市同德围地区女性生殖道支原体感染情况及耐药现状,并观察中西医结合治疗支原体感染的疗效,为临床提供参考依据。方法选择2018年1月—2019年12月于广州医科大学附属中医医院同德围院区妇科门诊就诊的736例女性生殖道感染患者作为研究对象,采用支原体鉴定及药敏试剂盒对所有患者生殖道分泌物进行支原体培养及药敏试验;选择相应抗菌药物并针对病因采取清热解毒、健脾祛湿的中医方法加以中药汤剂完带汤治疗。结果736例女性患者中检出泌尿生殖道支原体阳性77例,检出率为10.46%,其中解脲脲原体(Uu)阳性67例(占87.01%),人型支原体(Mh)阳性1例(占1.30%),Uu合并Mh阳性9例(占11.69%)。感染人群中31~40岁年龄段支原体阳性者所占比例最高〔44.16%(34/77)〕。药敏试验结果显示,多数支原体感染患者对美满霉素、交沙霉素和克拉霉素敏感性较高。治疗后,同德围地区女性生殖道支原体感染的复发率为0。结论同德围地区女性生殖道支原体感染以Uu为主,根据药敏试验结果合理使用抗菌药物,并加以中药辅助治疗效果更佳。Objective To analyze the mycoplasma infection and drug resistance of female genital tract in Tongdewei region,Guangzhou City,observe the therapeutic effect of integrated traditional Chinese and Western medicine and provide reference for clinical practice.Methods The 736 female patients with genital tract infection in department of gynaecology of Tongdewei section of the Affiliated Traditional Chinese Medicine Hospital of Guangzhou Medical University from January 2018 to December 2019 were selected,mycoplasma culture and drug sensitivity test were performed with mycoplasma identification and drug sensitivity kit.The corresponding antibiotics were selected,and Chinese medicine of clearing heat and detoxification,invigorating spleen and eliminating dampness and Wandai decoction were taken.Results Among 736 female patients,77 cases were positive for urogenital mycoplasma,accounting for 10.46%,including 67 cases(87.01%)of Ureaplasma urealyticum(Uu)positive,1 case(1.30%)of Mycoplasma hominis(Mh)positive,and 9 cases(11.69%)of Uu+Mh positive.The highest proportion of mycoplasma positive patients was 31-40 years old[44.16%(34/77)].Drug susceptibility results showed that patients with Uu,Mh simple infection or mixed infection were highly sensitive to minocycline,glucomycin and clarithromycin.After treatment,the recurrence rate of mycoplasma infection in Tongdewei area was 0.Conclusions The female genital mycoplasma in Tongdewei region was mainly Uu infection.The clinical use of antimicrobial drugs based on drug susceptibility results,and traditional Chinese medicine adjuvant treatment had better curative effect.

关 键 词：生殖道支原体 药物敏感性 中西医结合 

分 类 号：R446.5[医药卫生—诊断学]