广东省孕前优生检查对出生缺陷防控作用效果评价  

Efficiency of pre-pregnancy health check for eugenics on prevention and control of birth defects in Guangdong province

作　　者：陈水莲 梁志江[2] 黄冠豪 李兵[2] 夏建红[2] 赵庆国 CHEN Shui-lian;LIANG Zhi-jiang;HUANG Guan-hao(Health Care Department,Guangdong Women and Children’s Hospital Affiliated to Guangzhou Medical University,Guangzhou,Guangdong Province 511442,China;不详)

机构地区：[1]广州医科大学附属广东省妇儿医院保健部,广东广州511442 [2]广东省妇幼保健院 [3]广东省计划生育专科医院

出　　处：《中国公共卫生》2020年第9期1326-1330,共5页Chinese Journal of Public Health

摘　　要：目的评估广东省孕前优生健康检查对出生缺陷等不良妊娠结局的防控效果。方法选取广东省各地区2014-2017年参加孕前优生健康检查项目的1953746对育龄夫妇的监测信息进行回顾性分析。结果广东省共有1953746对育龄夫妇参加孕前优生检查项目,风险人群总检出率为37.36%。育龄妇女排在前5位的风险因素分别为孕前及孕早期未服用叶酸(40.28%)、常见生殖道感染(17.26%)、尿常规检查异常(16.61%)、生殖道检查异常(14.12%)和高龄(10.29%)。育龄男性排在前3位的风险因素为高龄(17.11%)、体格检查异常(10.95%)、生殖系统检查异常(9.45%)。共779722名育龄妇女被追踪到分娩或终止妊娠结局情况,总不良妊娠结局发生率为7.10%,总出生缺陷发生率为15.69/万。结论孕前优生健康检查项目对出生缺陷等不良妊娠结局的防控效果显著,大大降低出生缺陷发生率,应继续实施。Objective To evaluate the effect of pre-pregnancy health check for eugenics on prevention and control of adverse pregnancy outcome including birth defects in Guangdong province.Methods Surveillance data on 1953746 childbearing couples participating in the pre-pregnancy health checkup for eugenics in various regions of Guangdong province from 2014 through 2017 were collected for a retrospective analysis.Results Of all the participants surveyed during the period,37.36%were assessed with risk factors for having abnormal fetuses.The top five identified risk factors for birth defect among the childbearing women included not taking supplemental folic acid during early pregnancy(40.28%),common reproductive tract infection(17.26%),abnormality in urine test(16.61%),abnormality of reproductive tract(14.12%),and at elder age(10.29%);while,the top three risk factors for the men at childbearing age were at elder age(17.11%),abnormality in physical examination(10.95%),and abnormality in reproductive system(9.45%).A total of 779722 childbearing women were followed-up to their deliveries or pregnancy terminations.The incidence of total adverse pregnancy outcome was 7.10%,and the incidence of total birth defects was 15.69 per 10000 perinatal infants.Conclusion Pre-pregnancy health checkup for eugenics has significant effects on prevention and control of adverse pregnancy outcomes such as birth defects and the checkup should be carried out among childbearing couples continuously to reduce the incidence of birth defects.

关 键 词：免费孕前优生健康检查 出生缺陷 效果评价 

分 类 号：R172[医药卫生—妇幼卫生保健]