非血管性勃起功能障碍患者阴茎交感皮肤反应的变化  

Changes of penis sympathetic skin response in patients with non-vascular erectile dysfunction

作　　者：孙国海 汪珣 韩友峰[1] 戴玉田[1] 石亮[1] SUN Guohai;WANG Xun;HAN Youfeng;DAI Yutian;SHI Liang(Department of Andrology,Drum Tower Hospital Affiliated to Nanjing University School of Medicine,Nanjing 210008,China)

机构地区：[1]南京大学医学院附属鼓楼医院泌尿男科,南京210008

出　　处：《中华实用诊断与治疗杂志》2020年第9期906-908,共3页Journal of Chinese Practical Diagnosis and Therapy

基　　金：国家自然科学基金(81671452)。

摘　　要：目的探讨非血管性勃起功能障碍勃起易疲软者的阴茎交感皮肤反应(penis sympathetic skin response, PSSR)变化。方法阴茎勃起硬度评分4级、阴茎海绵体动脉收缩期峰值流速≥35 cm/s、舒张末期流速≤0 cm/s、PSSR能正常牵引出的勃起功能障碍患者71例,以阴茎海绵体注射血管活性药物后持续勃起时间>20 min者44例为勃起坚挺组,持续勃起时间<5 min者27例为勃起易疲软组。比较2组年龄、收缩期峰值流速、舒张末期流速及PSSR潜伏期、波幅差异。结果 2组年龄、舒张末期流速、PSSR波幅比较差异均无统计学意义(P>0.05)。勃起易疲软组左、右侧阴茎海绵体动脉收缩期峰值流速[(52.50±14.68)、(53.25±17.78)cm/s]低于勃起坚挺组[(66.23±18.38)、(64.36±19.40)cm/s](P<0.05),PSSR潜伏期[(1 198.15±109.34)ms]短于勃起坚挺组[(1 410.11±140.53)ms](P<0.05)。结论阴茎勃起易疲软者PSSR潜伏期缩短,可能存在交感神经高兴奋性,PSSR神经电生理检查可用于交感神经兴奋性较高的非血管性勃起功能障碍的辅助检测。Objective To investigate the changes of penis sympathetic skin response(PSSR) in nonpersistent erection patients with non-vascular erectile dysfunction(ED). Methods Seventy-one ED patients were screened out with penile erectile hardness score of 4, peak systolic velocity of bilateral penile cavernosal artery ≥ 35 cm/s, end diastolic velocity ≤0 cm/s and normal PSSR. After the penile intracavernous injection test, 71 patients were divided into 44 patients with sustained erection time >20 min(maintaining erection group) and 27 patients with sustained erection time <5 min(nonpersistent erection group). The age, peak systolic velocity, end diastolic velocity as well as the latency and amplitude of PSSR were compared between two groups. Results There were no significant differences in age, end diastolic velocity and PSSR amplitude between two groups(P>0.05). The left and right peak systolic velocities were lower in nonpersistent erection group((52.50±14.68),(53.25±17.78) cm/s) than those in maintaining erection group((66.23±18.38),(64.36±19.40) cm/s)(P<0.05). The PSSR latency was shorter in nonpersistent erection group((1 198.15±109.34) ms) than that in maintaining erection group((1 410.11±140.53) ms)(P<0.05). Conclusion The latency of PSSR is short in patients with nonpersistent erection, and the patients might have sympathetic hyperexcitability. The electrophysiological examination of PSSR could be used in the auxiliary detection of ED patients with sympathetic hyperexcitability.

关 键 词：勃起功能障碍 交感神经高兴奋性 阴茎交感皮肤反应 彩色多普勒超声 

分 类 号：R698[医药卫生—泌尿科学]