2型糖尿病神经病变发病机制研究进展  

Research Progress of Pathogenesis of Type 2 Diabetic Neuropathy

作　　者：李琳 高海波 苏晓清[2] LI Lin;GAO Hai-bo;SU Xiao-qing(The First Clinical Medical College of Gannan Medical College,Ganzhou,Jiangxi Province,341000 China;Department of Endocrinology,Pingxiang Hospital Affiliated to Gannan Medical College,Pingxiang,Jiangxi Province,337055 China)

机构地区：[1]赣南医学院第一临床医学院,江西赣州341000 [2]赣南医学院附属萍乡医院内分泌科,江西萍乡337055

出　　处：《糖尿病新世界》2020年第15期196-198,共3页Diabetes New World Magazine

摘　　要：糖尿病神经病变(diabetic neuropathy,DPN)是2型糖尿病患者最为常见的慢性并发症之一,是多种因素综合作用的结果。糖类、脂类代谢异常、氧化应激、慢性炎症反应、雪旺细胞的损伤等均参与其中。该文就与DPN发病机制相关的信号通路(JAK-STAT信号通路、ATF6信号通路)、雪旺细胞病变、自噬的表达、基因多态性在DPN发病中所起的作用进行概述。Diabetic neuropathy(DPN) is one of the most common chronic complications in patients with type 2 diabetes,which is the result of a combination of factors. Abnormal glucose metabolism, lipid metabolism, oxidative stress, chronic inflammation, and Schwann cell damage are all involved. This article summarizes the roles of signaling pathways related to the pathogenesis of DPN(JAK-STAT signaling pathway, ATF6 signaling pathway), Schwann cell disease, autophagy expression, and gene polymorphism in the pathogenesis of DPN.

关 键 词：糖尿病神经病变 信号通路 自噬 基因多态性 

分 类 号：R587.1[医药卫生—内分泌]