ABO血型不合肝移植患者与同血型肝移植患者他克莫司维持剂量的对比  

Comparison of maintenance dose of tacrolimus between ABO-incompatible liver transplantation patients and homologous liver transplantation patients

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作  者:罗丁[1] 赵雄齐[1] 王冬冬[1] 刘其雨[1] 陈刚[1] LUO Ding;ZHAO Xiong-qi;WANG Dong-dong(First People’s Hospital of Kunming,Kunming 650000,China)

机构地区:[1]昆明市第一人民医院,650000

出  处:《中国现代药物应用》2020年第18期115-117,共3页Chinese Journal of Modern Drug Application

摘  要:目的对比ABO血型不合肝移植患者与同血型肝移植患者的他克莫司(FK506)维持剂量及对肝功能的影响。方法选取9例行ABO血型不合肝移植患者作为观察组,另选取18例同血型肝移植患者作为对照组。记录比较两组患者他克莫司维持剂量及术后4个月的肝功能指标[血清丙转氨酶(ALT)、谷草转氨酶(AST)、总胆红素(TBIL)以及白蛋白(ALB)]。结果观察组患者他克莫司维持剂量为(0.092±0.023)mg/(kg·d),对照组患者他克莫司维持剂量为(0.071±0.025)mg/(kg·d);观察组患者他克莫司维持剂量显著高于对照组,差异有统计学意义(P<0.05)。观察组患者术后4个月血清ALT、AST、TBIL与ALB水平与对照组对比,差异无统计学意义(P>0.05)。结论对于ABO血型不合肝移植患者,达到他克莫司目的血药浓度,对肝功能影响及免疫抑制是安全可靠的。Objective To compare the maintenance dose of tacrolimus(FK506)between ABOincompatible liver transplantation patients and homologous liver transplantation patients and its influence on liver function.Methods There were 9 cases of ABO-incompatible liver transplantation patients as observation group,and another 18 cases of homologous liver transplantation patients as control group.The maintenance dose of tacrolimus and liver function indicators[serum alanine aminotransferase(ALT),aspartate aminotransferase(AST),total bilirubin(TBIL)and albumin(ALB)]4 months after operation was recorded and compared between the two groups.Results The maintenance dose of tacrolimus of the observation group was(0.092±0.023)mg/(kg·d),which was(0.071±0.025)mg/(kg·d)of the control group.The maintenance dose of tacrolimus of the observation group was significantly higher than that of the control group,and the difference was statistically significant(P<0.05).4 months after operation,there was no statistically significant difference in serum ALT,AST,TBIL and ALB,compared with that of the control group(P>0.05).Conclusion For patients with ABO-incompatible liver transplantation,the effect of blood concentration on liver function and immunosuppression after reaching the target of tacrolimus is safe and reliable.

关 键 词:肝移植 血型 他克莫司 维持剂量 肝功能 

分 类 号:R657.3[医药卫生—外科学]

 

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