循环microRNA在血管性认知障碍诊断中的应用  

Diagnostic potential of circulating microRNA in vascular cognitive impairment

作　　者：袁美 张新新 郭祎莎 毕霞 Yuan Mei;Zhang Xinxin;Guo Yisha;Bi Xia(Shanghai University of Sport,Shanghai 200438,China;Department of Rehabilitation Medicine,Affiliated Zhoupu Hospital,Shanghai University of Medicine&Health Sciences,Shanghai 201318,China)

机构地区：[1]上海体育学院,上海市200438 [2]上海健康医学院附属周浦医院康复医学科,上海市201318

出　　处：《中国组织工程研究》2021年第8期1299-1304,共6页Chinese Journal of Tissue Engineering Research

基　　金：上海市卫生健康委员会科研课题(201940031),项目负责人:毕霞;上海市浦东新区卫生和计划生育委员会领先人才培养项目(PWR12018-04),项目负责人:毕霞。

摘　　要：背景:目前血管性认知障碍缺乏客观且灵敏的实验室诊断指标。循环microRNA具有容易获取、收集无创、容易检测、特异性强及表达稳定的优势,可能是血管性认知障碍有前景的诊断指标。目的:综述国内外有关microRNA在血管性认知障碍诊断中的研究成果。方法:应用计算机检索PubMed,Web of Science,Scopus,Embase,OVID,CNKI和万方数据库2009年1月至2020年1月的相关文献,英文检索词为“microRNA,vascular cognitive impairment,post-stroke cognitive impairment,diagnosis,biomarker”,中文检索词为“microRNA,血管性认知功能障碍,脑卒中后认知功能障碍,诊断,生物标志物”,最终纳入42文献进行综述。结果与结论:相比于正常认知人群,在血管性认知障碍患者的血清、血浆和脑脊液中发现多种microRNA差异性表达,且部分miRNA的表达水平与认知功能障碍评分存在一定的相关性。此综述发现循环microRNA是一种新型的、有潜在诊断价值的血管性认知障碍的生物标志物。但目前研究存在样本量小、候选microRNA灵敏度特异度低等缺点,因此microRNA在血管性认知障碍的临床应用仍然有较大的发展空间。BACKGROUND:To date,vascular cognitive impairment(VCI)still lacks effective therapeutic strategy and objective diagnostic tool.Circulating microRNA is considered as a promising diagnostic biomarker due to its advantages of easy acquisition,non-invasive collection,easy detection,strong specificity,and stable expression.OBJECTIVE:To review domestic and foreign studies of microRNAs in VCI diagnosis.METHODS:Literatures published from January 2009 to January 2020 were searched in PubMed,Web of Science,Scopus,Embase,OVID,CNKI and WanFang databases with keywords of“microRNA,vascular cognitive impairment,post-stroke cognitive impairment,diagnosis,biomarker”in English and Chinese,respectively.Finally,42 literatures were included for analysis.RESULTS AND CONCLUSION:Compared with the normal cognitive population,differentially expressed microRNAs are found in the serum,plasma and cerebrospinal fluid of VCI patients,and the expression levels of some microRNAs are correlated with the cognitive assessment score.Taking together,circulating microRNA is a new biomarker with potential diagnostic value for VCI.However,the clinical application of microRNAs in VCI still has a large room for development due to the small sample size and low specificity or sensitivity of candidate microRNAs.

关 键 词：脑卒中 认知障碍 血管性 循环MICRORNA 脑脊液 生物标志物 综述 

分 类 号：R446[医药卫生—诊断学] R446[医药卫生—临床医学]