广西首起新型冠状病毒肺炎家庭聚集性疫情分析  

Analysis of the first family cluster of COVID-19 in Guangxi

作　　者：覃江龙 张剑锋[2] 卢祥婵[1] 朱庆东[1] 覃鸿发[1] 梁宝元 吴锋耀[1] QIN Jianglong;ZHANG Jianfeng;LU Xiangchan;ZHU Qingdong;QIN Hongfa;LIANG Baoyuan;WU Fengyao(The Fourth People's Hospital of Nanning,Nanning,Guangxi 530023,China;Second Affiliated Hospital of Guangxi Medical University,Nanning,Guangxi 530007,China)

机构地区：[1]南宁市第四人民医院,广西南宁530023 [2]广西医科大学第二附属医院,广西南宁530007

出　　处：《中国热带医学》2020年第9期875-878,共4页China Tropical Medicine

摘　　要：目的报道广西首次发生的一起家庭聚集性新型冠状病毒肺炎疫情的流行病学特征和临床特点。方法详细收集和分析一家庭10名成员中7名感染新型冠状病毒的流行病学、临床表现、实验室检查和放射影像学。结果2020年1月18日居住在武汉的6名成员从武汉来到南宁,并与居住在南宁的4名成员一起生活。6名居住在武汉的成员有4名感染新型冠状病毒。4名近期没有去过武汉居住在南宁的成员有3名感染新型冠状病毒。7名患者年龄中位数37岁,其中包括一名11岁儿童。从出现症状到确诊的时间为1~7 d。临床症状包括干咳(42.85%)、肌痛(42.85%)、发热(28.57%)、疲乏(28.57%)、咽痛(14.28%)、头晕(14.28%)、鼻塞(14.28%),没有患者出现呼吸困难。炎症标志物C反应蛋白和降钙素原正常。淋巴细胞计数减少3例(42.85%),CD4^+T淋巴细胞降低1例(16.67%)。5名患者肺部出现磨玻璃样病灶。结论新型冠状病毒肺炎可在家庭成员之间互相传播。我们需要重视家庭人与人之间的传染,加强家庭聚集性病例的管理。Objective To describe the epidemiological and clinical characteristics of a familial cluster of pneumonia associated with SARS-CoV-2.Methods We collected and analyzed the epidemiological,demographic,clinical,laboratory and radiological of seven patients in ten members of a family.Results On January 18,2020,six members who lived in Wuhan came to Nanning from Wuhan,and lived with four members who are lived in Nanning.Of six family members who lived in Wuhan,four were identified as infected with SARS-CoV-2.Additionally,of four family members who lived in Nanning and did not travel to Wuhan,three were identified as infected with SARS-CoV-2.The median age of the seven patients was 37 years,including an 11-year-old child.The time from first symptoms to diagnosis was one to seven days.Symptoms included dry cough(42.85%),myalgia(42.85%),fever(28.57%),fatigue(28.57%),pharyngalgia(14.28%),dizziness(14.28%)and rhinobyon(14.28%),none of the patients had dyspnea.Levels of inflammatory markers such as C-reactive protein and procalcitonin were normal.Lymphopenia was in 3 cases(42.85%),and reduced CD4^+lymphocyte in 1 case(16.67%).Ground glass opacity was observed in the lungs of five patients.Conclusion Pneumonia associated with SARS-CoV-2 can spread among family members.We need to focus on person-to-person transmission in family and the management of familial cluster of pneumonia associated with SARS-CoV-2.

关 键 词：家庭聚集性 新型冠状病毒 新型冠状病毒肺炎 

分 类 号：R563.14[医药卫生—呼吸系统]