3例新型冠状病毒肺炎患者不同标本检测分析  

Analysis of the test results of 3 cases from COVID-19 patients

作　　者：吴彪[1,2] 陈媛[2] 符娟[1] 符健[1] 王姣[1] 吴涛[1] 姚津剑[3] 林锋[1] WU Biao;CHEN Yuan;FU Juan;FU Jian;WANG Jiao;WU Tao;YAO Jinjian;LIN Feng(Department of Infection,Hainan General Hospital,Haikou,Hainan 570311,China;Office of Diseases Control and Prevention,Hainan General Hospital,Haikou,Hainan 570311,China;Emergency Department,Hainan General Hospital,Haikou,Hainan 570311,China)

机构地区：[1]海南省人民医院感染科,海南海口570311 [2]海南省人民医院疾病预防控制办公室,海南海口570311 [3]海南省人民医院急诊科,海南海口570311

出　　处：《中国热带医学》2020年第9期904-907,共4页China Tropical Medicine

基　　金：海南省社会发展基金(No.ZDYFXGFY2020004);白求恩·医学科学研究基金(No.SG070DS)。

摘　　要：目的分析新型冠状病毒肺炎(COVID-19)患者临床表现及治疗后咽拭子、粪便、尿液的严重急性呼吸综合征冠状病毒2(SARS-CoV-2)核酸检测阴转情况,探讨新型冠状病毒肺炎(COVID-19)病人的出院标准。方法回顾性分析3例海南省人民医院收治的COVID-19病例,对其临床表现及治疗后咽拭子、粪便、尿液的严重急性呼吸综合征冠状病毒2(SARS-CoV-2)核酸检测结果进行描述。结果3例COVID-19病例治疗后咽拭子核酸转阴性,粪便核酸检测仍呈阳性,合并尿液核酸阳性1例,1例患者病程3周后出现SARS-CoV-2抗体lgM、lgG均阳性(滴度分别为4.416和18.485)。结论建议严格把握出院标准,推荐增加粪便、尿液核酸检测,出院后仍需集中医学观察14 d以最大限度降低消化道传播风险的可能。Objective To analyze the clinical manifestations of coronavirus disease 2019(COVID-19)patients and the negative conversion of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)nucleic acid test in pharyngeal swabs,feces and urine after treatment,and we look forward to guide the clinical discharge control of patients with COVID-19.Methods Three cases of COVID-19 admitted to the Hainan General Hospital were analyzed retrospectively.The clinical manifestations and result testing for SARS-CoV-2 nucleic acids in throat swabs,stools and urine after treatment were analyzed.Results It is reported that 3 cases of COVID-19 patients in Hainan turned negative for nucleic acid of throat swab after treatment,stools nucleic acid test was still positive,1 case was urine nucleic acid positive,and 1 patient had SARS-CoV-2 antibody IgM and IgG positive after 3 weeks of discharge(The titers were 4.416 and 18.485 respectively).Conclusion It is suggested that in the future,discharge standards should be strictly controlled.It is recommended to increase stool and urine nucleic acid detection.After discharge,the medical observation should be concentrated for 14 days to minimize the risk of digestive tract transmission.

关 键 词：新型冠状病毒肺炎 严重急性呼吸综合征冠状病毒2 咽拭子 粪便 核酸 

分 类 号：R563.14[医药卫生—呼吸系统]