响应面法优化钙软胶囊的制备工艺  

Optimization of preparation process of Calcium soft capsule by response surface methodology

作　　者：张国文[1] 张桂美 胡明明[1,2] ZHANG Guowen;ZHANG Guimei;HU Mingming(State Key Laboratory of Food Science and Technology,Nanchang University,Nanchang 330047,China;Palm Oil Research and Technical Service Institute of Malaysian Palm Board,Shanghai 201108,China)

机构地区：[1]南昌大学食品科学与技术国家重点实验室,江西南昌330047 [2]大马棕榈油技术研发(上海)有限公司

出　　处：《南昌大学学报（理科版）》2020年第3期242-247,共6页Journal of Nanchang University(Natural Science)

基　　金：马来西亚棕榈油总署基金(PORTSIM058/2017)。

摘　　要：以沉降体积比和流动性为考察指标,经单因素试验筛选内容物基质、固液比和助悬剂的合理研究范围。以综合评分为响应值,用响应面分析法确定钙软胶囊内容物的配方。结果表明,优化后的各项参数为:内容物以58%熔点5℃棕榈油和42%(w/w)大豆油为基质,碳酸钙粉(400目)和基质质量比2:1(g/g),助悬剂蜂蜡加入量为基质的3%(w/w)。在优化后的条件下得到内容物的综合评分为98.51分(n=3)。所得软胶囊内容物稳定,流动性好,适于工业化生产。Single factor experiments were designed to select the content matrix,the ratio of solid to liquid and the suspending agent,by using sedimentation volume ratio and fluidity as indicators.With the comprehensive score as the response value,the prescription of the content in the calcium soft capsule was determined following the response surface methodology(RSM).The results showed that the optimized parameters of 58%5℃palm oil and 42%(w/w)soybean oil were used as a matrix.The ratio of the calcium powder(400 mesh)to the oil was 21(g/g),and the amount of suspended beeswax accounted for 3%(w/w)of the matrix.Under the optimized condition,the comprehensive score of content was 98.51(n=3).The contents of the obtained soft capsule were stable with high fluidity,while the end-shaping process was suitable for industrialization.

关 键 词：钙软胶囊 处方优化 响应面 沉降体积比 流动性 

分 类 号：O657.3[理学—分析化学]