多巴胺与GPTMS共修饰介孔硅及其对阿维菌素的缓释性能  

Dopamine and GPTMS co-modified mesoporous silica and its sustained release properties to avermectin

作　　者：温洪坚 蔡和晟 周红军[1,2] 郝丽 陈铧耀[2] 徐华[1] 周新华[1,2] WEN Hongjian;CAI Hesheng;ZHOU Hongjun;HAO Li;CHEN Huayao;XU Hua;ZHOU Xinhua(College of Chemistry and Chemical Engineering, Zhongkai University of Agriculture and Engineering, Guangzhou 510225, China;Key Laboratory of Agricultural Green Fine Chemicals of Guangdong Higher Education Institution, Zhongkai University of Agriculture and Engineering, Guangzhou 510225, China)

机构地区：[1]仲恺农业工程学院化学化工学院,广东广州510225 [2]仲恺农业工程学院广东省普通高校农用绿色精细化学品重点实验室,广东广州510225

出　　处：《仲恺农业工程学院学报》2020年第3期24-32,共9页Journal of Zhongkai University of Agriculture and Engineering

基　　金：国家自然科学基金(2157630);广东省自然科学基金(2017A030311003,2016A030313375)资助项目。

摘　　要：为实现阿维菌素对缓慢释放的有效调控,以十六烷基三甲基溴化铵(Cetyltrimethylammonium bromide,CTAB)为模板剂、正硅酸乙酯(Tetraethoxysilane,TEOS)为硅源、多巴胺和γ-(2,3-环氧丙氧)丙基三甲氧基硅烷(γ-(2,3-glycidoxy)propyltrimethoxysilane,GPTMS)为共同改性剂一锅合成改性介孔硅微球;以阿维菌素(Avermectin,AVM)为模型药物,采用湿法浸渍法成功制备AVM-改性介孔硅载药体系,并考察不同GPTMS用量的改性介孔硅在不同pH环境下对阿维菌素的释放性能.结果表明,随着改性用的多巴胺与GPTMS质量比从40∶0到40∶120,阿维菌素的累积释放率从64.6%减小为44.7%,有着较为明显的减小,说明GPTMS的加入有利于改善多巴胺改性介孔硅对阿维菌素的缓释性能.介孔硅在碱性条件下表现出较明显的pH响应性,当pH 10时,阿维菌素的累积释放率大于pH 3,其累积释放率分别为57.6%和43.6%.载药体系的释放行为可通过Korsmeyer-Peppas动力学模型来解释,且其扩散系数K2<0.45,说明阿维菌素的释放由Fickian扩散控制.In order to achieve effective regulation of sustained release of avermectin,a kind of modified mesoporous silica was prepared in this paper to achieve the goal.In this study,cetyltrimethylammonium bromide(CTAB)was used as a template,tetraethoxysilane(TEOS)as a silicon source,and dopamine andγ-(2,3-glycidoxy)propyltrimethoxysilane(GPTMS)as co-modifier to synthesis the modified mesoporous silica nanoparticles using one-pot method.Avermectin(AVM)was used as a model drug to prepare avermectin/modified mesoporous silica drug-loading system by wet impregnation,and the avermectin release performance of silica with the different modified dosage of GPTMS was investigated under the various pH conditions.The results showed that with the mass ratio of modified dopamine to GPTMS from 40∶0 to 40∶120,the cumulative release rate of avermectin decreased from 64.6%to 44.7%,which has a significant decrease,indicating that the addition of GPTMS is beneficial to improve the slow release performance of dopamine-modified mesoporous silica on avermectin.Moreover,mesoporous silica exhibited relatively obvious pH responsiveness under alkaline condition.At pH 10,the cumulative release rate of Avermectin was greater than that at pH 3,which were 57.6%and 43.6%,respectively.The sustained release behavior of the drug-loaded system could be explicated by the Korsmeyer-Peppas kinetic model,and its diffusion coefficient K2<0.45,indicating that the release of avermectin is regulated by Fickian diffusion.

关 键 词：多巴胺 γ-(2 3-环氧丙氧)丙基三甲氧基硅烷 介孔硅 阿维菌素 缓释性能 

分 类 号：TQ450.6[化学工程—农药化工]