通过调控肿瘤代谢增强T细胞抗肿瘤活性  

Enhancing T Cell Antitumor Activity by Regulating Tumor Metabolism

作　　者：张思佳 徐彩娜[1] 陈杰[1,2] 田华雨[1,2] 陈学思[1,2] ZHANG Sijia;XU Caina;CHEN Jie;TIAN Huayu;CHEN Xuesi(Key Laboratory of Polymer Ecomaterials,Changchun Institute of Applied Chemistry,Chinese Academy of Sciences,Changchun 130022,China;University of Science and Technology of China,Hefei 230026,China)

机构地区：[1]中国科学院长春应用化学研究所,中国科学院生态环境高分子材料重点实验室,长春130022 [2]中国科学技术大学,合肥230026

出　　处：《应用化学》2020年第9期977-984,共8页Chinese Journal of Applied Chemistry

基　　金：国家自然科学基金(51925305,51873208,51520105004,51833010);吉林省科技发展项目(20180414027GH)资助。

摘　　要：肿瘤免疫治疗是一种新型的癌症治疗方法。然而,现阶段肿瘤免疫疗法的临床响应率低等问题严重制约了其进一步应用。其根本原因在于肿瘤组织免疫抑制微环境限制了T细胞的抗肿瘤活性,而肿瘤组织代谢改变在肿瘤免疫抑制微环境形成过程中起关键作用。本文重点总结了通过调控肿瘤的有氧糖酵解、氨基酸代谢和脂肪酸代谢增强T细胞的抗肿瘤活性。最后,提出当前肿瘤代谢调控研究方面仍然存在的问题,并对纳米载体在肿瘤代谢领域的发展前景进行了展望。Tumor immunotherapy is a new technique for cancer treatment.However,the low clinical response rate of tumor immunotherapy at this stage seriously restricts its further application.The fundamental reason is that the immunosuppressive microenvironment of tumor tissue limits the antitumor activity of T cells,and the metabolic changes of tumor tissue play a key role in the formation of tumor immunosuppressive microenvironment.In this paper,we focus on enhancing the antitumor activity of T cells by regulating the aerobic glycolysis,amino acid metabolism and fatty acid metabolism of tumors.Finally,the current problems in the research of tumor metabolism regulation are proposed,and the development prospects of nanocarriers in the field of tumor metabolism are prospected.

关 键 词：肿瘤代谢 T细胞抗肿瘤活性 有氧糖酵解 氨基酸代谢 脂肪酸代谢 

分 类 号：O629[理学—有机化学]