磺胺嘧啶钠在淮南麻鸭体内药物动力学试验  

Pharmacokinetics of Sulfadiazine Sodium in Huainan Patridge Duck

作　　者：刘锦妮[1] 王向茹 吴海港[1] 姬万民 LIU Jin-ni;WANG Xiang-ru;WU Hai-gang;JI Wan-min(Xinyang Agriculture and Forestry University,Xinyang Engineering Research Center for New Veterinary Drug Research and Create,Xinyang 464000,China;Ringpu(Tianjin)Bio-technology Co.,Ltd,Konggang 300308,China)

机构地区：[1]信阳农林学院信阳市兽药新制剂研发与创制工程技术研究中心,河南信阳464000 [2]瑞普(天津)生物技术股份有限公司,天津空港300308

出　　处：《中国兽医杂志》2020年第4期97-100,共4页Chinese Journal of Veterinary Medicine

基　　金：河南省高等学校重点科研项目(19B230016);河南省科技攻关项目(182102110377)。

摘　　要：为了研究磺胺嘧啶钠在淮南麻鸭体内代谢过程,16只淮南麻鸭随机分成2组,每组8只,按100 mg/(kg·bw)的剂量分别口服和静脉注射磺胺嘧啶钠,评价其在血浆中的药动学特征。结果显示:本试验所建立的标准曲线相关性好,相关系数达0.99以上,日内变异系数小于5%,日间变异系数小于10%。磺胺嘧啶钠在淮南麻鸭体内吸收迅速,分布广泛,房室模型分析表明,药时数据均符合二室开放模型,口服给药下的主要药物动力学参数为:分布半衰期(t1/2α)为(4.61±0.94)h,消除半衰期(t1/2β)为(6.66±0.74)h,药时曲线下面积(AUC)为(395.06±24.03)(μg/mL)·h,达峰时间(Tp)为(3.71±0.84)h,峰浓度(Cmax)为(49.97±5.66)μg/mL。静脉注射条件下的主要药物动力学参数为:分布半衰期(t1/2α)为(0.62±0.08)h,消除半衰期(t1/2β)为(3.21±0.98)h,药时曲线下面积(AUC)为(385.14±13.52)(μg/mL)·h。To study the pharmacokinetics of sulfadiazine sodium in Huainan patridge ducks.16 Huainan patridge duck were divided into 2 groups,each group of 8,sulfadiazine sodium were administered orally and intravenously with a single dosage of 100 mg/(kg·bw)in the pharmacokinetics group.The results revealed that the correlation of calibration curves was all good,and the correlation coeffcients were more than 0.99.The intra-day and inter-day coefficients of variation were less than 5%and 10%,respectively.The pharmacokinetic characteristics of SD in crucian carp manifested rapid absorption and wide distribution.The plasma drug concentration-time data were fitted two-compartment open models,after intravenous administration,the disposition half-life(t1/2α)of the drug was(0.62±0.08)h,whereas the elimination half-life(t1/2β)of the drug was(3.21±0.98)h.The area under the serum concentration-time curve(AUC)was(385.14±13.52)(μg/mL)·h.After oral administration,the disposition half-life(t1/2α)of the drug was(4.61±0.94)h,whereas the elimination half-life(t1/2β)of the drug was(6.66±0.74)h.The area under the serum concentration-time curve(AUC)was(395.06±24.03)(μg/mL)·h.The time-point of maximum plasma concentration of the drug(Tmax)and the maximum plasma concentration(Cmax)were calculated as(3.71±0.84)h and(49.97±5.66)μg/mL.

关 键 词：磺胺嘧啶钠 淮南麻鸭 药物动力学 

分 类 号：S834[农业科学—畜牧学]