18例老年侵袭性肺部真菌感染临床分析  

Clinical analysis of 18 confirmed elderly patients with invasive pulmonary fungal infection

作　　者：周霞[1] 谢明萱[2] 陈琼[3] 李坑[4] ZHOU Xia;XIE Mingxuan;CHEN Qiong;LI Keng(Department of Pediatrics,Xiangya Hospital,Central South University,Changsha,Hunan 410008,China;Department of Geriatrics,Xiangya Hospital,Central South University,Changsha,Hunan 410008,China;National Clinical Research Center for Geriatric Disorders,Xiangya Hospital,Central South University,Changsha,Hunan 410008,China;Department of Respiratory Medicine,the Second Xiangya Hospital,Central South University,Changsha,Hunan 410011,China)

机构地区：[1]中南大学湘雅医院儿科,湖南长沙410008 [2]中南大学湘雅医院老年病科,湖南长沙410008 [3]中南大学湘雅医院国家老年疾病临床医学研究中心,湖南长沙410008 [4]中南大学湘雅二医院呼吸内科,湖南长沙410011

出　　处：《中国医学工程》2020年第9期9-12,共4页China Medical Engineering

摘　　要：目的探讨老年人侵袭性肺部真菌感染的临床特征,加深对老年人侵袭性肺部真菌感染的认识。方法对2013年5月至2019年5月中南大学湘雅医院及中南大学湘雅二医院收治的确诊侵袭性肺部真菌感染老年住院患者的临床资料进行回顾性分析。结果本研究入选患者18例,曲霉菌感染9例,白色念珠菌感染5例,热带念珠菌1例,白色念珠菌合并曲霉菌感染3例。均存在真菌感染的危险因素,有肺部基础疾病者17例,长期应用广谱抗生素者11例、长期使用激素者7例、低蛋白血症9例,进行过侵入性操作者13例、接受放化疗者2例,合并病毒性肺炎者2例。其中手术切除2例,均治愈,15例给予抗真菌药物治疗。结论老年患者易并发侵袭性肺部真菌感染,临床上应及早诊断和治疗,降低病死率。【Objective】To discuss the clinical characteristics and get a deeper understanding of invasive pulmonary fungal infection in elderly people.【Methods】Clinical materials of elderly inpatients with confirmed invasive pulmonary fungal infection treated in Xiangya Hospital and the Second Xiangya Hospital from May 2013 to May 2019 were retrospectively analyzed.【Results】Eighteen cases were included,among them,9 with aspergillus,5 with candida albican,4 with both candida albican and aspergillus,1 with candida tropicalis.All of them had susceptible factors of fungal infection.Seventeen cases had pulmonary underlying diseases;11 cases had been applied by broad-spectrum antibiotics;7 cases had a long history of hormone;9 cases had hypoproteinemia;13 cases were applied by invasive operations;2 were undertaken chemotherapy;2 combined with viral pneumonia.In the end,2 cases were surgically removed and cured;15 were undertaken anti-fungal therapy.【Conclusion】Elderly patients are more susceptible to invasive pulmonary fungal infection.We should take early diagnosis and treatment to lower its fatality rate.

关 键 词：肺疾病 真菌性 老年 诊断 侵袭性肺部真菌感染 

分 类 号：R563[医药卫生—呼吸系统]