莫西沙星注射液相关的老年呼吸系统感染患者低钾血症危险因素分析  

Risk factors of moxifloxacin-induced hypokalemia in elderly patients with respiratory infection

作　　者：顾贝欣 吴建博 沈杰 高宁舟 周海峰 熊野娟 GU Beixin;WU Jianbo;SHEN Jie;GAO Ningzhou;ZHOU Haifeng;XIONG Yejuan(School of Pharmacy,Shanghai University of Medicine&Health Sciences,Shanghai 201318,China)

机构地区：[1]上海健康医学院药学院,上海201318 [2]复旦大学附属华东医院药剂科 [3]上海市浦东医院药剂科

出　　处：《中国感染与化疗杂志》2020年第5期502-505,共4页Chinese Journal of Infection and Chemotherapy

摘　　要：目的探讨莫西沙星注射液治疗老年呼吸系统感染患者致低钾血症的相关危险因素,为临床莫西沙星的安全应用提供依据。方法采用回顾性研究方法,选取2016年1月-2018年12月使用莫西沙星注射液治疗的老年呼吸系统感染363例住院患者,对可能引起低钾血症的危险因素进行单因素及logistic回归分析。结果363例患者中,47例发生低钾血症,发生率为12.9%。logistic回归分析结果显示,禁食、腹泻和合并使用利尿剂3个因素对莫西沙星注射液致低钾血症的发生有显著影响(P<0.05)。结论使用莫西沙星前应充分评估患者的基础情况(禁食、腹泻),加强对合并使用利尿剂患者的血钾及生命指标的监护,若发生低钾血症应及时予以纠正,保证临床用药的安全性。Objective To investigate the related risk factors for hypokalemia in elderly patients with respiratory system infection who received moxifloxacin injection,and to provide evidence for safe use of moxifloxacin.Methods Retrospective analysis was conducted on 363 elderly inpatients who were treated with moxifloxacin injection from January 2016 to December 2018.The risk factors of hypokalemia were explored by univariate and logistic regression analyses.Results Hypokalemia was identified in 47(12.9%)of the 363 patients.Logistic regression analysis showed that fasting,diarrhea,and diuretics use significantly affected the occurrence of moxifloxacin-induced hypokalemia(P<0.05).Conclusions We should fully evaluate the underlying conditions(fasting,diarrhea)of patients and pay attention to the monitoring of blood potassium and vital signs in case of diuretics use before moxifloxacin therapy.If hypokalemia occurs,it is of great clinical significance to correct it in time to ensure the safety of clinical medication.

关 键 词：莫西沙星注射液 低钾血症 危险因素 

分 类 号：R978[医药卫生—药品]