0~3岁住院婴幼儿急性呼吸道感染的病毒检测结果分析  

Clinical analysis of virus detection results of acute respiratory tract infections in infants and young children aged 0 to 3 years old

作　　者：钟永兴 王卓英 章建伟 严菊英 ZHONG Yongxing;WANG Zhuoying;ZHANG Jianwei;YAN Juying(Department of Pediatrics,Women and Children′s Hospital of Shaoxing City,Shaoxing,Zhejiang 312000,China)

机构地区：[1]浙江省绍兴市妇女儿童医院儿内科,312000

出　　处：《重庆医学》2020年第18期3037-3040,共4页Chongqing medicine

基　　金：浙江省医药卫生计划项目(2018KY847)。

摘　　要：目的探讨0~3岁住院婴幼儿急性呼吸道感染常见病毒的流行特点。方法收集2017年11月至2018年10月该院住院急性呼吸道感染的1122例0~3岁婴幼儿临床资料,住院当日或次日采集鼻咽拭子标本,用直接免疫荧光法(DFA)检测7种常见病毒抗原,分析比较常见病毒感染的流行特点。结果1122例患儿中,共251例患儿至少检出7种常见病毒中的1种;检出率前三位病毒分别为呼吸道合胞病毒(RSV)136例(54.23%)、副流感病毒Ⅲ(PIV-3)56例(22.31%)、流感病毒A(IVA)24例(9.56%)。其中29 d至6月龄组病毒检出率为27.80%(120/432),7月龄至1岁组病毒检出率为25.00%(71/284),<1~2岁组病毒检出率为18.62%(46/247),<2~3岁组病毒检出率为8.81%(14/159)。本组病例中急性上呼吸道感染328例,病毒检出率为16.46%(54/328)。急性下呼吸道感染794例,病毒检出率为24.79%(197/794);急性上呼吸道感染病毒检出率低于急性下呼吸道感染。在急性上呼吸道感染中PIV-3检出率最高,在急性下呼吸道感染中RSV检出率最高,分别为6.40%(21/328)、15.36%(122/794)。男性患儿病毒检出率为21.39%(135/631),女性患儿病毒检出率为23.63%(116/491),两者比较差异无统计学意义(P>0.05)。结论针对急性呼吸道感染患儿进行常见呼吸道病毒的检测,有助于呼吸道病毒的监控,对早期明确病原体及合理用药均具有积极意义。Objective To explore the epidemic characteristics of common acute respiratory tract infections in infants and children aged 0 to 3 years old.Methods A total of 1122 cases of infants and young children aged 0 to 3 years old with acute respiratory tract infections in this hospital from November 2017 to October 2018 were collected.Nasopharyngeal swabs were collected on the day of hospitalization or the next day,and the specimens were detected by direct immunofluorescence(DFA)of 7 kinds of common viral antigens.The epidemic characteristics of common virus infections were analyze and compare.Results Among 1122 cases of infants and children,251 cases were detected at least one of the 7 common virus;the top three virus detected were 136 cases(54.23%)of respiratory syncytial virus(RSV),56 cases(22.31%)of parainfluenzaⅢvirus(PIV-3),24 cases(9.56%)of influenza virus A(IVA).Among them,the virus detection rate was 27.80%(120/432)in the 29-days to 6-months-old group,25.00%(71/284)in the 7-months-old to 1-year-old group,and 18.62%(46/247)in the<1-2 years old group,8.81%(14/159)in the<2-3 years old group.There were 328 cases of acute upper respiratory infections in this group of cases,and the virus detection rate was 16.46%(54/328).There were 794 cases of acute lower respiratory infections,and the virus detection rate was 24.79%(197/794).The detection rate of acute upper respiratory infection virus is lower than that of acute lower respiratory infection virus.The detection rate of PIV-3 was the highest in acute upper respiratory infections,and the detection rate of RSV was the highest in acute lower respiratory infections,which were 6.40%(21/328)and 15.36%(122/794),respectively.The virus detection rate of male children was 21.39%(135/631),and that of female children was 23.63%(116/491),the difference was not significant(P>0.05).Conclusion The detection of respiratory viruses in infants and young children with acute respiratory infection is helpful for the monitoring of respiratory viruses,and has positive significance for ear

关 键 词：婴幼儿 0~3岁 急性呼吸道感染 病毒 流行病学 

分 类 号：R725[医药卫生—儿科]