贫血对晚期肺癌患者临床病理特点与生存状况的影响  

Effect of anemia on clinicopathological characteristics and survival status of patients with advanced lung cancer

作　　者：齐志峰[1] 张章[1] 江伟[1] 秦岭[1] 吴越菲[1] 管睿[1] 韦永明[1] QI Zhifeng;ZHANG Zhang;JIANG Wei;QIN Ling;WU Yuefei;GUAN Rui;WEI Yongming(Department of Oncology,the Second People′s Hospital of Wuhu City,Wuhu,Anhui 241000,China)

机构地区：[1]安徽省芜湖市第二人民医院肿瘤内科,241000

出　　处：《重庆医学》2020年第18期3049-3052,共4页Chongqing medicine

基　　金：安徽省自然科学基金资助项目(1708085QH210)。

摘　　要：目的探究贫血对晚期肺癌患者临床病理特点与生存状况的影响。方法回顾性分析2015年1月至2018年1月该院收治的168例晚期肺癌患者的临床资料,其中92例贫血患者为贫血组,76例无贫血患者为非贫血组。比较贫血组和非贫血组患者的临床病理特点和生存状况,Cox多因素分析贫血状况与生存状况的相关性。结果92例贫血患者中多为轻度(52.19%)和中度(42.39%)贫血,贫血类型多为慢性疾病性贫血(ACD,79.34%),以正细胞(65.22%)为主要形态。与非贫血组比较,贫血组患者的病程短、肿瘤直径小、营养预后指数(PNI)>45占比高、临床分期为Ⅳ期占比高、美国东部肿瘤协作组(ECOG)评分高、远处转移和淋巴结转移发生率高,差异均有统计学意义(P<0.05)。贫血组患者的转移率(80.43%)和1年内病死率(26.09%)也高于非贫血组患者(68.42%,17.10%),差异有统计学意义(P<0.05)。Cox多因素分析结果显示,发生贫血和贫血程度为晚期肺癌患者生存状况的独立危险因素(P<0.05)。结论晚期肺癌贫血发生率高,贫血患者病程短,远处转移和淋巴结转移发生率高。Objective To investigate the effect of anemia on the clinicopathological features and survival status of patients with advanced lung cancer.Methods The clinical data of 168 patients with advanced lung cancer admitted to this hospital from January 2015 to January 2018 were retrospectively analyzed.Among them,92 patients with anemia were divided into the anemia group and 76 patients without anemia were divided into the non-anemic group.The clinicopathological characteristics and survival status of patients in the anemia group and the non-anemia group were compared,and Cox multivariate analysis was done to analysis the correlation between anemia status and survival status.Results Among the 92 patients with anemia,mild(52.19%)and moderate(42.39%)anemia were common.The anemia type was mostly ACD(79.34%),with positive cells(65.22%)as the main form.Compared with the non-anemic group,patients in the anemia group had a shorter course of disease,a smaller tumor diameter,a higher proportion of nutritional prognosis index(PNI)>45,a high proportion of clinical stage ofⅣ,a higher ECOG score,a higher incidence of distant metastasis and lymph node metastasis,the differences were statistically significant(P<0.05).The metastatic rate(80.43%vs.68.42%,)and the 1-year mortality rate(26.09%vs.17.10%)were higher in the anemia group than in the non-anemic group,and the differences were statistically significant(P<0.05).Cox multivariate analysis showed that the degree of anemia and anemia were independent risk factors for the survival status of patients with advanced lung cancer(P<0.05).Conclusion The incidence of anemia in patients with advanced lung cancer is high,patients with advanced lung cancer complicated with anemia have a shorter course of disease,and higher incidence of lymph rode metastasis.

关 键 词：肺肿瘤 晚期 贫血 临床病理特点 生存状况 

分 类 号：R556[医药卫生—血液循环系统疾病]