血清CCL4水平和绝经后骨质疏松症严重程度相关性研究  

Correlation between serum CCL4 level and severity of postmenopausal osteoporosis

作　　者：杨剑 李清雪[2] 仝瑞晓[3] 陈景伟[4] YANG Jian;LI Qingxue;TONG Ruixiao;CHEN Jingwei(Department of Rehabilitation, Youfu Hospital, Hebei Province, Shijiazhuang 050051, China;Department of Gynecology, Shijiazhuang No. 4 Hospital, Shijiazhuang 050011, China;Department of Gynecology, Bengbu Hospital of Traditional Chinese Medicine, Handan 056000, China;Department of Obstetrics and Gynecology of Integrated Traditional and Western Medicine, Hebei College of Traditional Chinese Medicine, Handan 050200, China)

机构地区：[1]河北省优抚医院康复科,河北石家庄050051 [2]石家庄市第四医院妇科,河北石家庄050011 [3]邯郸市中医院妇科,河北邯郸056000 [4]河北中医学院中西医结合妇产科学教研室,河北邯郸050200

出　　处：《中国骨质疏松杂志》2020年第10期1490-1494,共5页Chinese Journal of Osteoporosis

摘　　要：目的探讨血清CCL4水平与绝经后骨质疏松症(PMOP)严重程度的关系。方法对66名PMOP女性,68名绝经后非骨质疏松女性和67名健康育龄妇女进行研究。用双能X射线吸收测定法扫描评估骨密度。Oswestry残疾指数和视觉模拟量表用于量化症状的活动功能和严重程度。用定量夹心酶联免疫吸附测定血清CCL4水平。结果发现CCL4血清水平与骨密度呈显著负相关。此外,血清CCL4水平与视觉模拟评分和Oswestry残疾指数评分显著相关。结论血清CCL4是评估PMOP女性疾病严重程度的潜在生物标志物。Objective To explore the relationship between serum CCL4 level and the severity of postmenopausal osteoporosis(PMOP).Methods This research enrolled 66 PMOP females,68 post-menopausal nonosteoporotic women and 67 healthy women of childbearing age.Bone mineral densities were assessed with dual X-ray absorptiometry scans.The Oswestry disability index and the visual analog scale were employed to quantify functional ability and severity of symptoms.Serum CCL4 levels were examined with a quantitative sandwich enzyme-linked immunosorbent assay.Results We observed a significant negative correlation of CCL4 serum levels with bone mineral density.Furthermore,serum CCL4 concentrations were significantly related to the visual analog scale and Oswestry Disability Index scores.Conclusion Serum CCL4 is a potential biomarker to evaluate disease severity in PMOP females.

关 键 词：CCL4 骨密度 绝经后骨质疏松症 疾病严重程度 

分 类 号：R58[医药卫生—内分泌]