HLA-B27相关性急性前葡萄膜炎的中医体质调查  

Investigation of TCM constitution of HLA-B-associated acute anterior uveitis

作　　者：姜小涵 李艳 王毓琴 卢纯洁 赵颖熙 向圣锦 JIANG Xiaohan;LI Yan;WANG Yuqin;LU Chunjie;ZHAO Yingxi;XIANG Shengjin(Department of Chinese Ophthalmology,Eye Hospital of Wenzhou Medical University,Wenzhou 325027,China)

机构地区：[1]温州医科大学附属眼视光医院中医眼科,浙江温州325027

出　　处：《温州医科大学学报》2020年第9期758-761,共4页Journal of Wenzhou Medical University

基　　金：温州医科大学附属眼视光医院院内创新引导项目(YNCX201305)。

摘　　要：目的:通过调查分析并总结HLA-B27相关性急性前葡萄膜炎患者静止期中医体质的特点和分布规律。方法:纳入门诊有急性前葡萄膜炎病史,但现阶段无眼部炎症症状患者共332例,分为HLA-B27(+)组和HLA-B27(-)组,分析2组患者中医体质特点和分布规律。结果:332例患者中,总体体质类型为单一体质患者295例,复合体质者37例共兼含75种体质类型,共计332例患者合370种体质类型。HLA-B27(+)组185例患者中,单一体质类型者164例,其中平和体质98例,病理体质66例;复合体质者21例兼含43种体质类型。HLA-B27(-)组147例患者中,单一体质类型者131例,其中平和体质97例,病理体质34例;复合体质者16例兼含32种体质类型。HLA-B27(+)组病理体质患者比例较HLA-B27(-)组更高(P<0.05);且HLA-B27(+)组湿热体质患者比例也较HLA-B27(-)组更高(P<0.05)。结论:HLA-B27相关性急性前葡萄膜炎是一类具有同类体质易感性的疾病,但其静止期体质以平和质为主;相对于HLA-B27(-)急性前葡萄膜炎患者,HLA-B27(+)急性前葡萄膜炎患者病理体质总体比例更高,且有更多湿热体质患者。Objective:To investigate and summarize the characteristics and distribution patterns of Chinese Traditional Medicine(TCM)constitution in quiescent stage of acute anterior uveitis patients with HLA-B27 positive,so as to provide more theoretical information for clinical prevention and treatment.Methods:There were 322 patients of acute anterior uveitis in quiescent stage included in this study.The participants were divided into HLA-B27(+)group and HLA-B27(-)group according to HLA-B27 gene test results,and their TCM constitution characteristics and distribution were analyzed.Results:Of all 332 patients,there were 295 cases of single constitution type and 37 cases of combined constitution with 75 physical types,which meant a total of 332 patients with 370 constitution types in this study.Of the 185 cases of HLA-B27(+)patients,the constitution type of single physical,mild physical,pathological physical and complex physical were 164,98,66 and 21 cases,respectively.The complex physical type contained 43 different kinds of physical types.In contrast,of the 147 cases of HLAB27(-)patients,the constitution type of single physical,mild physical,pathological physical and complex physical were 131,97,34 and 16 cases,respectively.The complex physical type contained 32 different kinds of physical types.Therefore,HLA-B27(+)group had a higher proportion of pathological constitution and damp heat constitution,which showed statistical significance between them(P<0.05).Conclusion:HLA-B27-associated acute anterior uveitis is a disease with similar physical susceptibility,but in quiescent stage mild physical constitution is dominated.Compared with HLA-B27(-)patients with acute uveitis,the pathological constitution overall proportion of patients with HLA-B27(+)patients with acute uveitis was higher,and there were more patients with damp-heat constitution.

关 键 词：急性前葡萄膜炎 HLA-B27 体质 

分 类 号：R276.7[医药卫生—中医五官科学]