肾源性系统性纤维化1例  

A Case of Nephrogenic Systemic Fibrosis

作　　者：耿雯瑾 赵月婷 曾贞 陈凤娟 刘彤云[1] GENG Wenjin;ZHAO Yueting;ZENG Zhen;CHEN Fengjuan;LIU Tongyun(Department of Dermatology,the First Affiliated Hospital of Kunming Medical University,Kunming 650032,China;Department of Dermatology,Eastern Hospital of the Sixth People's Hospital of Shanghai,Shanghai 201306,China)

机构地区：[1]昆明医科大学第一附属医院皮肤科,云南昆明650032 [2]上海市第六人民医院东院皮肤科,上海201306

出　　处：《中国皮肤性病学杂志》2020年第10期1170-1172,共3页The Chinese Journal of Dermatovenereology

摘　　要：患者男,49岁,双下肢皮肤红斑、变硬3个月,既往因慢性肾功能衰竭行肾移植术。皮肤科情况:双下肢大小不一片状、不规则肿胀性暗红斑,部分融合,边界不清,质硬,呈橘皮样。皮损组织病理示:真皮全层弥漫纤维化,延伸至皮下脂肪小叶间隔,并见梭形细胞增生。免疫组织化学:梭形细胞CD34阳性。诊断:肾源性系统性纤维化。A 49-year-old male presented erythema and hardened skin on both lower extremities for three months,who underwent kidney transplantation due to chronic renal failure.Skin examination found the two lower extremities are uneven in size,irregularly swollen dark erythema,partially fused,with unclear borders,hard texture,and orange peel-like appearance.Histopathological examination showed the collagen bundles throughout the reticular dermis and extending into the septae of subcutaneous fat,and the proliferation of spindle cells.Immunostaining showed the spindle cells positivity for CD34.The diagnosis of nephrogenic systemic fibrosis was made.

关 键 词：肾源性系统性纤维化 肾疾病 造影剂 

分 类 号：R593.25[医药卫生—内科学]