支气管哮喘气道炎症表型分布、气道炎症标志物检测及其与哮喘控制相关性分析  

Phenotypic distribution of bronchial asthma airway inflammation,airway inflammation markers detection and correlation analysis of asthma control

作　　者：王晓晟[1] 赵雪 孙宝华[1] WANG Xiaosheng;ZHAO Xue;SUN Baohua(Ward 1,Respiratory and Critical Care Medicine,Cangzhou Central Hospital,Hebei Province,Cangzhou061000,China)

机构地区：[1]河北省沧州市中心医院呼吸与危重症医学科一科,河北沧州061000

出　　处：《中国医药导报》2020年第26期120-123,共4页China Medical Herald

摘　　要：目的探讨支气管哮喘气道炎症表型分布、气道炎症标志物检测及其与哮喘控制的相关性,为患者临床治疗提供指导。方法回顾性分析河北省沧州市中心医院2016年5月—2019年5月确诊的110例哮喘患者的诊疗情况,按照患者哮喘控制水平分为完全控制组(20例)、部分控制组(41例)和未控制组(49例)。对三组支气管哮喘患者气道炎症表型分布情况进行分析,气道炎症标志物进行检测,Pearson相关分析法对哮喘控制水平与气道炎症标志物[呼出气一氧化氮(FeNO)、血清总免疫球蛋白(IgE)、痰嗜酸粒细胞、血嗜酸粒细胞]的相关性进行分析。结果三组气道炎症表型分布比较,差异无统计学意义(P>0.05);三组气道炎症标志物比较,差异无统计学意义(P>0.05);支气管哮喘控制水平与痰嗜酸粒细胞、FeNO、血嗜酸粒细胞、血清总IgE均无相关性(P>0.05)。结论支气管哮喘控制水平与气道炎症标志物无显著相关性,是否将气道炎症标志物检测作为1项判别支气管哮喘控制水平,还需根据患者个体情况及后续研究来确定。Objective To investigate the phenotypic distribution of bronchial asthma airway inflammation,airway inflammation markers detection and correlation analysis of asthma control,so as to provide clinical treatment guidance for patients.Methods The diagnosis and treatment of 110 asthma patients who diagnosed in Cangzhou Central Hospital of Hebei Province from May 2016 to May 2019 were retrospectively analyzed.According to the asthma control level,they were divided into complete control group(20 cases),partial control group(41 cases)and uncontrolled group(49 cases).The phenotypic distribution of airway inflammation in three groups of patients with bronchial asthma were analyzed,markers of airway inflammation were detected and the correlation between asthma control level and airway inflammation markers(exhaled nitric oxide[FeNO],serum total immunoglobulin[IgE],sputum eosinophils,blood eosinophils)were analyzed by Pearson correlation analysis.Results There were no significant differences in phenotype distribution of airway inflammation among three groups(P>0.05).There were no significant differences in markers of airway inflammation among three groups(P>0.05).There were no correlation between bronchial asthma control level and sputum eosinophils,FeNO,blood eosinophils and serum total IgE(P>0.05).Conclusion There is no significant correlation between asthma control level and airway inflammation markers,whether airway inflammation markers should be used to determine the control level of bronchial asthma still needs to be determined based on individual patient conditions and subsequent studies.

关 键 词：支气管哮喘 气道炎症 表型分布 标志物 哮喘控制 检测 

分 类 号：R562.65[医药卫生—呼吸系统]