黄体酮联合盐酸利托君片治疗习惯性流产的效果及对患者sHLA-G、EmAb、B7-2水平的影响  

Effect of progesterone combined with ritodrine hydrochloride tablets in the treatment of habitual abortion and its effect on sHLA-G,EMAb and B7-2

作　　者：丁丹妮 贺鑫[1] 杨伟辉 DING Danni;HE Xin;YANG Weihui(Department of Obstetrics,Hu'nan General Hospital(First Affiliated Hospital of Hunan Normal University),Changsha 410000,Hu'nan,China)

机构地区：[1]湖南省人民医院(湖南师范大学第一附属医院)产科,长沙410000

出　　处：《中国性科学》2020年第8期44-48,共5页Chinese Journal of Human Sexuality

基　　金：长沙市科技局项目(kq1901059)。

摘　　要：目的研究黄体酮联合盐酸利托君片治疗习惯性流产的效果及对患者可溶性人白细胞抗原(sHLA-G)、子宫内膜抗体(EmAb)、B7-2的影响。方法选取2017年1月至2018年1月湖南省人民医院(湖南师范大学第一附属医院)诊治的100例习惯性流产患者作为研究对象。分为单药治疗组(n=50)和联合治疗组(n=50)。两组患者均行常规的主动免疫治疗,单药治疗组患者使用黄体酮胶囊进行治疗,联合治疗组患者联合应用黄体酮胶囊、盐酸利托君片治疗。检测两组患者治疗前后激素、临床症状积分、sHLA-G、EmAb和B7-2水平,统计治疗效果、不良反应发生情况及妊娠结局。结果两组患者治疗前P、E2、HCG、sHLA-G、EmAb、B7-2水平和临床症状积分比较,差异无统计学意义(P>0.05);治疗后两组患者P、E2、HCG、sHLA-G、B7-2水平均高于治疗前,临床症状积分、EmAb水平低于治疗前,且联合治疗组患者P、E2、HCG、sHLA-G、B7-2水平高于单药治疗组,临床症状积分、EmAb水平低于单药治疗组,差异均具有统计学意义(均P<0.05)。联合治疗组患者治疗总有效率、妊娠成功率均高于单药治疗组,差异均具有统计学意义(均P<0.05)。联合治疗组患者总不良反应发生率高于单药治疗组,但两组间差异无统计学意义(P>0.05)。结论使用黄体酮联合利托君治疗习惯性流产,可显著改善患者临床症状,调节激素水平,改善sHLA-G、EmAb、B7-2异常表达,妊娠成功率较高,效果显著。Objective To study the effect of progesterone combined with ritodrine hydrochloride tablets on patients with habitual abortion and its effects on the soluble human leukocyte antigen(sHLA-G),endometrial antibody(EmAb)and B7-2 of patients.Methods From January 2017 to January 2018,100 patients with habitual abortion diagnosed and treated by Hunan People′s Hospital were divided into single drug treatment group and combined treatment group,with 50 cases each.Patients in the single drug treatment group were treated with progesterone capsule,and patients in the combined treatment group were treated with progesterone capsule and ritodrine hydrochloride tablets.Before and after treatment,the levels of hormone,clinical symptom score,sHLA-G,EMAb and B7-2 were measured,and the treatment effect,adverse reactions and pregnancy outcome were counted.Results There was no statistically significant difference in levels of P,E2,HCG,sHLA-G,EmAb and B7-2 and clinical symptom scores between the two groups before treatment(P>0.05).After treatment,the levels of P,E2,HCG,sHLA-G and B7-2 in the two groups were higher than those before treatment,and the clinical symptom scores and EmAb levels were lower than those before treatment,and the levels of P,E2,HCG,sHLA-G and B7-2 in the combined treatment group were higher than those of single drug treatment group,and the clinical symptom score and EmAb level were lower than those of single drug treatment group,all with statistically significant differences(all P<0.05).The total effective rate and pregnancy success rate of the combined treatment group were higher than those of the single drug treatment group,with statistically significant differences(all P<0.05).The incidence of total adverse reactions in the combined treatment group was higher than that in the single drug treatment group,but there was no statistically significant difference between the two groups(P>0.05).Conclusions Progesterone combined with ritodrine in the treatment of habitual abortion can significantly improve the clinical

关 键 词：黄体酮 盐酸利托君片 习惯性流产 可溶性人白细胞抗原 子宫内膜抗体 

分 类 号：R714[医药卫生—妇产科学]