新生儿溶血病与孕妇血型、孕龄及IgG效价的关系及相关影响因素探讨  

Relationship between hemolytic disease of newborns and blood type,gestational age and IgG titer of pregnant women and related influencing factors

作　　者：孟海华 马全福 陈生祥 MENG Haihua;MA Quanfu;CHEN Shengxiang(Department of Blood Transfusion,Fifth People's Hospital of Qinghai Province,Xining 810007,Qinghai,China;Department of Blood Transfusion,Qinghai Red Cross Hospital,Xining 810007,Qinghai,China)

机构地区：[1]青海省第五人民医院输血科,西宁810007 [2]青海红十字医院输血科,西宁810007

出　　处：《中国性科学》2020年第8期81-84,共4页Chinese Journal of Human Sexuality

摘　　要：目的分析新生儿溶血病(HDN)与孕妇血型、孕龄及IgG效价的关系,并探讨相关影响因素。方法选取2018年1月至2018年12月青海省第五人民医院和青海红十字医院接生的2768例新生儿及其母亲作为研究对象。根据是否患HDN将研究对象分为HDN组(n=190)和非HDN组(n=2578),对比两组研究对象的临床资料;分析HDN患病率及其与孕妇血型、孕龄及IgG效价的关系,用Logistic多因素回归分析导致HDN的独立危险因素。结果HDN组和非HDN组性别比差异无统计学意义(P>0.05),但孕妇年龄及妊娠次数比较,差异具有统计学意义(P<0.05),HDN组≥35岁及妊娠次数≥2次以上孕妇占比高于非HDN组,差异具有统计学意义(P<0.05)。在HDN患病新生儿中,以ABO型溶血和高龄(≥35岁)孕妇占比较大。IgG(抗O)各效价比较,差异具有统计学意义(P<0.0167),以≥1∶512效价HDN患病率最高。经Logistic多因素回归分析得知,≥35岁、≥2次妊娠次数及IgG效价≥1∶512孕妇是导致新生儿HDN发生的独立危险因素,差异具有统计学意义(P<0.05)。结论新生儿溶血与孕妇血型、孕龄及IgG效价密切相关,而孕妇≥35岁、妊娠次数≥2次及IgG效价≥1∶512是导致新生儿HDN发生的独立危险因素。Objective To analyze the relationship between hemolytic disease of newborns(HDN)and blood type,gestational age and IgG titer of pregnant women,and to explore the related influencing factors.Methods A total of 2768 newborns born in the Fifth People′s Hospital of Qinghai Province and Qinghai Red Cross Hospital from January 2018 to December 2018 and their mothers were collected and divided into HDN group and non-HDN group according to whether they suffered from HDN,190 cases and 2578 cases respectively.The relationship between the prevalence of HDN and blood type,gestational age and IgG titer of pregnant women was analyzed.The independent risk factors of HDN were analyzed by logistic regression analysis.Results There was no significant difference in gender between HDN group and non-HDN group(P>0.05),but there was statistically significant difference in the age of pregnant women and the number of pregnancies(P<0.05).The proportion of pregnant women over 35 years old and with at least two pregnancies in the HDN group was higher than that in the other group,with statistically significant differences(P<0.05).Among the newborns with HDN,ABO hemolysis and elderly pregnant women(≥35 years old)accounted for a larger proportion.The difference in IgG(anti-O)titers was statistically significant(P<0.0167),and the prevalence of HDN with titer≥1∶512 was the highest.The Logistic multivariate regression analysis showed that pregnant women≥35 years old,≥2 times of pregnancy and IgG titer≥1∶512 were independent risk factors for HDN in newborns(P<0.05).Conclusions Neonatal hemolysis is closely related to blood type,gestational age and IgG titer of pregnant women.Pregnant women≥35 years old,≥2 times of pregnancy and IgG titer≥1∶512 are independent risk factors for HDN in newborns.

关 键 词：新生儿溶血病 孕妇血型 孕龄 IgG效价 相关影响因素 

分 类 号：R714[医药卫生—妇产科学]