妊娠期糖尿病患者血清Vaspin、Omentin水平与胰岛素抵抗的关系  

Relationship between levels of serum Vaspin and Omentin and insulin resistance in patients with gestational diabetes mellitus

作　　者：李蕊珊 张志珊 欧阳春梅 吴雪琴[1] 符青松[2] LI Ruishan;ZHANG Zhishan;OUYANG Chunmei;WU Xueqin;FU Qingsong(Obstertrics Department,Shenzhen Longgang Central Hospital,Shenzhen 518116,Guangdong,China;Clinical Laboratory,Obstetrics Department,Shenzhen Longgang Central Hospital,Shenzhen 518116,Guangdong,China)

机构地区：[1]深圳市龙岗中心医院产科,广东深圳518116 [2]深圳市龙岗中心医院检验科,广东深圳518116

出　　处：《中国性科学》2020年第9期50-53,共4页Chinese Journal of Human Sexuality

基　　金：深圳市龙岗区经济与科技发展专项资金医疗卫生科技计划项目(LGKCYLWS2018000038)。

摘　　要：目的探讨妊娠期糖尿病(GDM)患者血清中内脏脂肪组织源性丝氨酸蛋白酶抑制剂(Vaspin)、网膜素(Omentin)水平与胰岛素抵抗之间的关系。方法选取2018年1月至2019年1月深圳市龙岗中心医院诊治的120例妊娠24周~32周孕妇作为研究对象。将这120例孕妇分为观察组(n=60)和对照组(n=60),观察组为GDM患者,对照组为正常妊娠者。采用酶联免疫吸附法(ELISA)测定两组孕妇血清中Vaspin、Omentin水平;同时检测两组孕妇血糖、血脂以及胰岛素有关指标,并分析观察组孕妇血清中Vaspin、Omentin水平与血糖、血脂以及胰岛素有关指标的相关性,另分析影响GDM发生的危险因素。结果观察组孕妇血清Vaspin水平高于对照组孕妇,差异具有统计学意义(P<0.05);观察组孕妇血清Omentin水平低于对照组孕妇,差异具有统计学意义(P<0.05);两组孕妇空腹血糖(FPG)、空腹胰岛素(FINS)、胰岛素抵抗指数(HOMA-IR)、总胆固醇(TC)以及三酰甘油(TG)相比,观察组孕妇明显高于对照组孕妇,差异具有统计学意义(P<0.05);经Pearson法分析,孕妇血清Vaspin与FPG、FINS、HOMA-IR、TC以及TG均呈正相关,差异具有统计学意义(P<0.05),孕妇血清Omentin与FPG、FINS以及HOMA-IR均呈负相关,差异具有统计学意义(P<0.05);多元素回归分析结果显示,Vaspin、Omentin、FPG、HOMA-IR是GDM的危险因素。结论Vaspin在GDM孕妇血清中呈现高表达,Omentin呈现低表达,二者均与胰岛素抵抗程度及孕妇糖、脂代谢紊乱有关,可能参与GDM疾病的发生和发展。Objective To investigate the relationship between levels of serum visceral adipose tissue-derived serine protease inhibitor(Vaspin)and Omentin and insulin resistance in patients with gestational diabetes mellitus(GDM).Methods From January 2018 to January 2019,120 pregnant women aged 24-32 weeks in Shenzhen Longgang central hospital were selected as the research objects.The 120 pregnant women were divided into observation group(n=60)and control group(n=60),the observation group was patients with gestational dia-betes,and the control group was normal pregnanc.The levels of serum Vaspin and Omentin were measured by enzyme-linked immuno sorbent assay(ELISA).At the same time,the blood sugar,blood lipid and insulin related indicators of the two groups were detected,and the correlations between Vaspin,Omentin and blood sugar,blood lipid,insulin related indicators of the observation group were analyzed,the risk factors of GDM were also analyzed.Results The serum Vaspin level of pregnant women in the observation group was higher than that in the control group,with statistically significant differences(P<0.05).The serum Omentin level of pregnant in the observation group was lower than that in the control group,with statistically significant differences(P<0.05).The fasting blood glucose(FPG),fasting insulin(FINS),insulin resistance index(HOMA-IR),total cholesterol(TC)and triglyceride(TG)of the observation group were significantly higher than those of the control group,with statistically significant differences(P<0.05).Pearson analysis showed that serum Vaspin was positively correlated with FPG,FINS,HOMA-IR,TC and TG,with statistically significant differences(P<0.05),while serum Omentin of pregnant was negatively correlated with FPG,FINS and HOMA-IR,with statistically significant differences(P<0.05).Multivariate regression analysis showed that Vaspin,Omentin,FPG and HOMA-IR were risk factors for GDM.Conclusions Vaspin is highly expressed in the serum of pregnant women patients and Omentin is low expressed.Both of them are re

关 键 词：妊娠期糖尿病 内脏脂肪组织源性丝氨酸蛋白酶抑制剂 网膜素 胰岛素抵抗 

分 类 号：R714[医药卫生—妇产科学]