TGF-β1、NGFR、MMP-3在子宫腺肌病异位病灶中的表达及其与痛经的相关性研究  

Expression of TGF-β1,NGFR and MMP-3 in ectopic focus of adenomyosis and their correlation with dys-menorrhea

作　　者：谢凤云 毕宏 杨美霞 XIE Fengyun;BI Hong;YANG Meixia(Department of Gynaecology,Fuyang Women's and Children's Hospital,Fuyang Anhui 236000)

机构地区：[1]阜阳市妇女儿童医院妇科,安徽阜阳236000

出　　处：《中国性科学》2020年第9期115-119,共5页Chinese Journal of Human Sexuality

摘　　要：目的研究转化生长因子-β1(TGF-β1)、神经生长因子受体(NGFR)、基质金属蛋白酶-3(MMP-3)在子宫腺肌病异位病灶中的表达及其与痛经的相关性。方法选择2018年4月至2019年4月阜阳市妇女儿童医院接收的62例行子宫切除治疗的子宫腺肌病患者作为研究对象,并将其子宫异位内膜和在位内膜设为子宫腺肌病组,另选取60例同期因宫颈上皮内瘤变(CIN)Ⅱ及Ⅲ接受子宫切除患者子宫正常内膜设为对照组。比较两组TGF-β1、NGFR、MMP-3表达情况。结果子宫腺肌病组中,异位内膜和在位内膜TGF-β1、NGFR、MMP-3阳性表达率的比较,差异无统计学意义(P<0.05);与对照组比较,异位内膜TGF-β1、NGFR、MMP-3阳性表达率明显较高,差异具有统计学意义(P<0.05)。子宫腺肌病增生期、分泌期异位内膜、在位内膜TGF-β1、NGFR、MMP-3阳性表达率比较,差异无统计学意义(P>0.05);子宫腺肌病增生期、分泌期异位内膜TGF-β1、NGFR、MMP-3阳性表达率均高于对照组,差异具有统计学意义(P<0.05)。又将子宫腺肌病异位内膜患者分为痛经组(n=50)和无痛经组(n=12),再将痛经组进一步细分为无或轻度痛经组(n=24)和中度及重度痛经组(n=38)。子宫腺肌病异位内膜病经组TGF-β1、NGFR、MMP-3阳性表达率高于无痛经组,差异具有统计学意义(P<0.05)。子宫腺肌病异位内膜中度及重度痛经组TGF-β1、NGFR、MMP-3阳性表达率高于无或轻度痛经组,差异具有统计学意义(P<0.05)。结论TGF-β1、NGFR和MMP-3在子宫腺肌病异位病灶中呈高表达,且随着痛经程度增加其阳性表达率相应上升。Objective To study the expression of transforming growth factor-β1(TGF-β1),nerve growth factor receptor(NGFR),matrix metalloproteinase-3(MMP-3)in ectopic lesions of adenomyosis and their correlation with dysmenorrhea.Methods Between April 2018 and April 2019,62 cases of ectopic endometrium and eutopic endometrium of patients with adenomyosis who underwent hysterectomy and were accepted by Fuyang Women and Children's Hospital were selected for research.The 62 cases of ectopic endometrium and eutopic endo-metrium were set as the uterine fibroids group,and another 60 cases of cervical intraepithelial neoplasia(CIN)II and III who underwent hysterectomy during the same period were selected as the control group.The expression of TGF-β1,NGFR and MMP-3 were compared between the two groups.Results In the uterine myomatosis group,the positive expression rates of TGF-β1,NGFR and MMP-3 in the ectopic and eutopic endometrium were not statis-tically significant(P<0.05).Compared with the control group,the positive expression rate of TGF-β1,NGFR and MMP-3 in the ectopic endometrium was significantly higher(P<0.05).There was no significant difference in the positive expression rates of TGF-β1,NGFR and MMP-3 in the proliferative,secretory and ectopic endometrium of adenomyosis(P>0.05).The positive expression rates of TGF-β1,NGFR and MMP-3 in the ectopic endometrium during the proliferation and secretion phases of adenomyosis were higher than those in the control group(P<0.05).The patients with ectopic endometrial adenomyosis were divided into dysmenorrhea group(n=50)and no dysmen-orrhea group(n=12),and the dysmenorrhea group was further subdivided into non-relieving dysmenorrhea group(n=24)and moderate to severe dysmenorrhea group(n=38).The positive expression rate of TGF-β1,NGFR and MMP-3 in the adenomyosis ectopic endometriosis group was higher than that in the non-dysmenorrhea group(P<0.05).The positive expression rate of TGF-β1,NGFR and MMP-3 in the ectopic endometrium of adenomyosis with moderate and severe dysmenorr

关 键 词：子宫腺肌病 转化生长因子-β1 神经生长因子受体 基质金属蛋白酶-3 

分 类 号：R711[医药卫生—妇产科学]