水相中可见光催化腈合成苯并咪唑衍生物  

Visible-Light Promoted Preparation of Benzimidazoles by Eosin Y Catalyzed Reaction of Benzonitrile Derivatives in Water

作　　者：林媚[1] 吴凡 刘天惠 陈志涛 许秀枝[1] 柯方[1,2] Lin Mei;Wu Fan;Liu Tianhui;Chen Zhitao;Xu Xiuzhi;Ke Fang(Department of Pharmacy,Fujian Medical University,Fuzhou 350004;Fujian Provincial Key Laboratory of Natural Medicine Pharmacolog,Fuzhou 350004)

机构地区：[1]福建医科大学药学院,福州350004 [2]福建省天然药物药理学重点实验室,福州350004

出　　处：《有机化学》2020年第8期2563-2569,共7页Chinese Journal of Organic Chemistry

基　　金：福建省自然科学基金(Nos.2016Y9052,2016Y9053,2017J01820)资助项目。

摘　　要：报道了在水相中可见光下1,2-苯二胺与苯腈的环化反应,合成了一系列苯并咪唑类化合物.反应用便宜、易处理、对环境无污染的曙红Y作为光催化剂.室温下在水相中反应,获得的产物有较好收率,最高产率可达到91%.提供了一种合成苯并咪唑类化合物的简便经济的方法.A novel visible-light-introduced reaction for the construction of benzimidazole derivatives via radical cyclization of o-phenylenediamines with benzonitrile derivatives in water has been developed.The reaction has been achieved in high yield under mild conditions by using Eosin Y as photocatalyst,which is cheap,easy to handle and environmentally friendly.A variety of benzimidazoles were obtained in up to 91%yields.It might provide a promising protocol for the synthesis of benzimidazole derivatives.

关 键 词：可见光 曙红Y 苯并咪唑 催化剂 

分 类 号：O626.23[理学—有机化学]