肝窦内皮细胞免疫表型的研究进展  

Research progress of liver sinusoidal endothelial cells’ immunophenotype

作　　者：陈睿[1] 洪茂林 曾仲[1] Chen Rui;Hong Maolin;Zeng Zhong(Department of Organ Transplantation,The First Affiliated Hospital of Kunming Medical University;Department of Hepatobiliary Surgery,The Second Affiliated Hospital of Kunming Medical University)

机构地区：[1]昆明医科大学第一附属医院器官移植中心,昆明650000 [2]昆明医科大学第二附属医院肝胆外科,昆明650000

出　　处：《重庆医科大学学报》2020年第9期1290-1293,共4页Journal of Chongqing Medical University

基　　金：国家自然科学基金地区科学基金资助项目(编号:81960124、81960123)。

摘　　要：分离、鉴定肝窦内皮细胞是研究其生理功能的基础,而免疫表型是分离、鉴定的关键。然而,肝窦内皮细胞缺乏特异性的免疫表型,成为其研究中的重大挑战。肝窦内皮细胞的免疫表型随不同阶段肝脏的功能转变而转换,并受肝小叶内代谢微环境的影响和细胞因子的调控,其免疫表型具有异质性。本文就肝窦内皮细胞免疫表型的表达、生理功能、异质性表现及成因进行综述,并简要分析目前其相对特异性的免疫表型研究进展。Isolation and identification of liver sinusoidal endothelial cells(LSECs) are the bases to study their physiological functions,and immunophenotype is the key to this work. However,the lack of specific immunophenotype on LSECs is the major challenge in their researches. The immunophenotype of LSECs is transformed with the functional changes of the liver at different stages,influenced by the metabolic microenvironment in hepatic lobules and regulated by cytokines,with the property of heterogeneity. This article reviewed the expression,physiological functions,heterogeneity and causes of LSECs ’ immunophenotype and briefly analyzed the research advances of the LSECs’ immunophenotype.

关 键 词：肝窦内皮细胞 免疫表型 异质性 肝腺泡 

分 类 号：R333.4[医药卫生—人体生理学]