没药中倍半萜类化学成分研究  

Studies of sesquiterpenes from Myrrha

作　　者：刘冠科 李思瑶 丁丽琴[2] 王莉宁[1] 邱峰[1,2] LIU Guan-ke;LI Si-yao;DING Li-qin;WANG Li-ning;QIU Feng(School of Chinese Materia Medica,Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China;Tianjin Key Laboratory of Modern Chinese Medicine,Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China)

机构地区：[1]天津中医药大学中药学院,天津301617 [2]天津中医药大学天津市现代中药重点实验室,天津301617

出　　处：《中草药》2020年第13期3372-3377,共6页Chinese Traditional and Herbal Drugs

基　　金：国家重点研发计划资助(2019YFC1711000);西青区鼓励高端制造创新驱动发展项目(cgzh-cgk-201801)。

摘　　要：目的研究没药属没药Commiphora myrrha的倍半萜类化学成分。方法采用硅胶、Sephadex LH-20、ODS等多种柱色谱,结合制备液相等方法进行分离和纯化,根据理化性质及波谱数据对化学成分进行结构鉴定。结果从没药二氯甲烷提取物中分离得到10个倍半萜类化合物,分别鉴定为11-methoxyl-guaia-6,10-dien-4α-ol(1)、(1R,4S,5R,10R)-isodauc-6-en-10,14-diol(2)、 10α-hydroxy-isodauc-6-en-14-al(3)、 guaia-6,10-dien-4α,11-diol(4)、 orientalolB(5)、(1S,4R,5R,10S)-isodauc-6-en-10,14-diol (6)、(1S,4S,5R,10S)-isodauc-6-en-10,14-diol (7)、alismanoid C (8)、guaiandiol (9)、canangaterpene Ⅵ (10)。结论化合物1为新化合物,命名为没药醇A。化合物2~10均为首次从该属植物中分离得到。Objective To study the chemical constituents from Myrrha. Methods The compounds were isolated and purified by column chromatography over silica gel, Sephadex LH-20, RP-ODS and preparative RP-HPLC. Their structures were elucidated by physicochemical properties and spectral analyses. Results Ten sesquiterpenes were isolated and identified as 11-methoxylguaia-6,10-dien-4α-ol(1),(1 R,4 S,5 R,10 R)-isodauc-6-en-10,14-diol(2), 10α-hydroxy-isodauc-6-en-14-al(3), guaia-6,10-dien-4α,11-diol(4), orientalol B(5),(1 S,4 R,5 R,10 S)-isodauc-6-en-10,14-diol(6),(1 S,4 S,5 R,10 S)-isodauc-6-en-10,14-diol(7), alismanoid C(8), guaiandiol(9) and canangaterpene Ⅵ(10). Conclusion Compound 1 is a new compound, named as commiphorol A and compounds 2—10 are isolated from the genus for the first time.

关 键 词：没药 倍半萜 没药醇A 10α-hydroxy-isodauc-6-en-14-al orientalol B alismanoid C guaiandiol canangaterpeneⅥ 

分 类 号：R284.1[医药卫生—中药学]