对叶百部化学成分研究  

Chemical constituents of Stemona tuberosa

作　　者：安巧 邹吉斌[3] 姜阳明 梁光焰 胡占兴 郝小江 AN Qiao;ZOU Ji-bin;JIANG Yang-ming;LIANG Guang-yan;HU Zhan-xing;HAO Xiao-jiang(State Key Laboratory of Functions and Applications of Medicinal Plants,Guizhou Medical University,Guiyang 550014,China;Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences,Guiyang 550014,China;Guizhou Medical University,Guiyang 550025,China)

机构地区：[1]省部共建药用植物功效与利用国家重点实验室,贵州贵阳550014 [2]贵州省中国科学院天然产物化学重点实验室,贵州贵阳550014 [3]贵州医科大学,贵州贵阳550025

出　　处：《中草药》2020年第13期3378-3382,共5页Chinese Traditional and Herbal Drugs

基　　金：国家自然科学基金委联合基金(U1812403);贵州医科大学2018年度学术新苗培养及创新探索专项项目(黔科合平台人才[2018]5779-60);贵州省科技计划项目(黔科合基础[2020]1Y398)。

摘　　要：目的研究百部科百部属对叶百部Stemonatuberosa的化学成分。方法采用反相C18、硅胶、凝胶柱色谱、制备型HPLC等方法进行分离纯化,通过理化性质、光谱数据结合参考文献鉴定化合物结构。结果从对叶百部根部甲醇提取物中分离鉴定10个化合物,分别鉴定为6-甲氧基-3-甲基-2H-吡喃-2-酮(1)、stilbostemin A(2)、stilbostemin K(3)、stilbostemin P(4)、stilbostemin Q(5)、stilbostemin R(6)、stilbostemin T(7)、stilbostemin W(8)、stilbostemin X(9)、stilbostemin Y(10)。结论化合物1为新的吡喃酮,命名为对叶百部吡喃酮A,化合物2、3为首次从该植物中分离得到。Objective To study the chemical constituents of Stemona tuberosa. Methods The chemical constituents were isolated and purified by chromatography with RP-C18, silica gel, Sephadex LH-20 and semi-preparative HPLC, and their structures were identified by analysis of spectroscopic data and physicochemical properties as well as relevant references. Results Ten compounds were isolated from the roots of S. tuberosa, and they were elucidated as 6-methoxy-3-methyl-2 H-pyran-2-one(1), stilbostemin A(2), stilbostemin K(3), stilbostemin P(4), stilbostemin Q(5), stilbostemin R(6), stilbostemin T(7), stilbostemin W(8), stilbostemin X(9) and stilbostemin Y(10). Conclusion Compound 1 is the new pyrone derivative named as stemonapyrone A. Compounds 2 and 3 are isolated from the plant of S. tuberosa for the first time.

关 键 词：百部科 对叶百部 茋类化合物 6-甲氧基-3-甲基-2H-吡喃-2-酮 对叶百部吡喃酮A stilbostemin A stilbostemin K 

分 类 号：R284.1[医药卫生—中药学]