新疆一枝蒿的化学成分研究  

Chemical constituents of Artemisia rupestris

作　　者：夏少立 曹悦 李庆林[1] 程志红[2] XIA Shao-li;CAO Yue;LI Qing-lin;CHENG Zhi-hong(Key Laboratory of Xin’an Medicine,Ministry of Education,Anhui University of Chinese Medicine,Hefei 230038,China;Department of Natural Medicine,School of Pharmacy,Fudan University,Shanghai 201203,China)

机构地区：[1]安徽中医药大学新安医学教育部重点实验室,安徽合肥230038 [2]复旦大学药学院天然药物学系,上海201203

出　　处：《中草药》2020年第13期3393-3398,共6页Chinese Traditional and Herbal Drugs

基　　金：国家自然科学基金面上项目(81473421)。

摘　　要：目的研究一枝蒿Artemisia rupestris干燥带根全草的化学成分。方法采用硅胶柱色谱、SephadexLH-20凝胶柱色谱及半制备高效液相色谱法分离纯化;通过核磁共振、质谱等波谱数据分析鉴定化合物的结构。结果从一枝蒿全草70%乙醇提取物的石油醚和醋酸乙酯萃取物中共分离得到18个化合物,分别鉴定为2α-(2′,4′-hexadiynoyl)-1,6-dioxaspiro[4,5]-deca-3-ene(1)、大黄酚(2)、香草酸乙酯(3)、亚麻酸甲酯(4)、8,11-十八碳二烯酸甲酯(5)、香豆酸二十烷酯(6)、大黄素(7)、2,5-二叔丁基苯酚(8)、珊瑚菜内酯(9)、紫丁香酸(10)、7-甲氧基香豆素(11)、香草醛(12)、欧前胡素(13)、千层纸素A(14)、5-羟基-3,4′,6,7-四甲氧基黄酮(15)、芥酸酰胺(16)、octadecyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl) propanoate(17)和3,5,3′,4′-四羟基-6,7-二甲氧基黄酮(18)。结论除化合物1、4、11~14和18为首次从该植物中分离得到外,其余化合物均为首次从蒿属植物中分离得到。Objective To investigate the chemical constituents of the whole plants of Artemisia rupestris. Methods The chemical constituents were isolated and purified by silica gel, Sephadex LH-20 column chromatography and semi-preparative HPLC. The structures of the isolated compounds were identified by NMR and MS spectroscopic method. Results Eighteen compounds were isolated and purified, which structures were identified as 2α-(2′,4′-hexadiynoyl)-1,6-dioxaspiro [4,5]-deca-3-ene(1), chrysophanol(2), ethyl vanillate(3), methyl linolenate(4), 8,11-octadecadienoic acid methyl ester(5), eicosane coumaric acid ester(6), emodin(7), 2,5-di-tert-butylphenol(8), phellopterin(9), syringic acid(10), 7-methoxycoumarin(11), vanillin(12), imperatorin(13), oroxylin A(14), 5-hydroxy-3,4′,6,7-tetramethoxyflavone(15), erucylamide(16), octadecyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl) propanoate(17) and 3,5,3′,4′-tetrahydroxy-6,7-dimethoxyflavone(18). Conclusion Compounds 1, 4, 11—14 and 18 are isolated from A. rupestris for the first time, and all the other compounds were isolated from the genus Artemisia for the first time.

关 键 词：一枝蒿 聚炔 珊瑚菜内酯 7-甲氧基香豆素 欧前胡素 千层纸素A 

分 类 号：R284.1[医药卫生—中药学]