松萝属地衣化学成分及生物活性研究进展  

Research progress on chemical constituents and their bioactivities of Usnea lichens

作　　者：刘冰倩 王晶晶[2] 贾妍 张磊 窦志英[1] 郝昱 张莉莉 王莉宁[1] LIU Bing-qian;WANG Jing-jing;JIA Yan;ZHANG Lei;DOU Zhi-ying;HAO Yu;ZHANG Li-li;WANG Li-ning(School of Chinese Materia Medica,Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China;Tianjin Institute of Pharmaceutical Research,Tianjin 300301,China)

机构地区：[1]天津中医药大学中药学院,天津301617 [2]天津药物研究院,天津300301

出　　处：《中草药》2020年第13期3585-3595,共11页Chinese Traditional and Herbal Drugs

基　　金：国家自然科学基金青年科学基金项目:药用地衣中内生菌抗菌活性物质的研究(81202444);天津市应用基础及前沿技术研究计划面上基金项目:药用地衣中松萝酸类化合物快速发现、结构修饰及抗耐药细菌生物被膜的活性研究(18JCYBJ28900)。

摘　　要：松萝属地衣在我国有着几千年的药用历史,其特殊的菌藻共生体系促生了独特的药用价值。具有清热解毒、舒筋活血、清肝明目、止咳化痰等传统功效,主治痰疟、感染和外伤等,入方剂可治温疫、水肿病症。松萝属地衣主要含有多取代单苯环类、二苯并呋喃类、缩酚酸类等化学成分,二苯并呋喃类及缩酚酸类是其主要活性成分。松萝属地衣粗提物及单体化合物具有抗菌、抗肿瘤、调脂及保肝等多种生物活性。现对近年来松萝属地衣化学成分及生物活性研究进展进行综述,为后续开发利用提供参考。Usnea lichens, as traditional Chinese medicine, has an extraordinary long history. It is well known for its medicinal uses due to the unique symbiosis of bacteria and algae. The symbiosis promotes the unique medicinal values. Its traditional functions involve clearing heat and detoxifying, relaxing tendon and activating blood, clearing liver and improving eyesight, relieving cough and eliminating phlegm, etc. They are mainly used for treating diseases such as phlegm malaria, infection, trauma, etc. They can cure plague, edema, and other diseases in the formula. Usnea lichens contain secondary metabolites such as multi-substituted monobenzenes, dibenzofurans, depsides, etc. Dibenzofurans and depsides are the main active ingredients. The crude extracts and compounds derived from Usnea lichens possess potent antimicrobial, antitumor, lipid-lowering, and liver-protecting activities. This paper reviews the research progress on the chemical constituents and biological activities of Usnea lichens in recent years, which provides reference values for further development and utilization of them.

关 键 词：松萝属 地衣 化学成分 生物活性 抗肿瘤 抗菌 保肝 

分 类 号：R285[医药卫生—中药学]