以“材料化学工程”理念构建“基于膜过程的中药绿色制造工程理论、技术体系”的探索  

Exploratory research into theories and system for membrane technology based on green manufacturing of Chinese materia medica-An emerging concept construction based on material-chemical engineering

作　　者：钟文蔚 郭立玮 袁海[1] 陈顺权 ZHONG Wen-wei;GUO Li-wei;YUAN Hai;CHEN Shun-quan(Guangdong Key Laboratory of Membrane Materials and Membrane Separation,Guangzhou Institute of Advanced Technology,Guangzhou 511458,China;Guangzhou Nansha Information Technology Park Post-doctoral Scientific Research Station,Guangzhou 511458,China;Jiangsu Botanical Medicine Refinement Engineering Research Center,Nanjing University of Chinese Medicine,Nanjing 210023,China;National and Local Joint Engineering Research Center of Inorganic Membrane,Jiangsu Jiuwu Hi-Tech Co.,Ltd.,Nanjing 211808,China)

机构地区：[1]广州中国科学院先进技术研究所广东省膜材料与膜分离重点实验室,广东广州511458 [2]广州南沙资讯科技园有限公司博士后科研工作站,广东广州511458 [3]南京中医药大学植物药深加工工程研究中心,江苏南京210023 [4]江苏久吾高科技股份有限公司无机膜国家地方联合工程研究中心,江苏南京211808

出　　处：《中草药》2020年第14期3609-3616,共8页Chinese Traditional and Herbal Drugs

基　　金：国家自然科学基金资助项目(30572374);国家自然科学基金资助项目(30171161);国家自然科学基金资助项目(30873449);国家自然科学基金资助项目(81274096);国家科技部“十五”科技攻关计划项目(2004BA721A42);国家科技部“十一五”科技支撑计划项目(2006BAI09B07-03);国家科技部重点研发计划“中医药现代化研究”重点专项(2019YFC1711300);2017中国工程院咨询项目(2017-XZ-08);广州市科技项目(201904010054)。

摘　　要：中药膜科技具有重大国家科技战略需求,是我国中药制药工业亟需推广的高新技术。中药制药技术主要来源于化学工程领域,其分离技术的提升与产业的升级主要依赖于化学工程的发展。在紧密围绕膜技术在中药制药工业的产业化应用所开展的中药绿色制造关键技术研究工作基础上,结合成功申报"中医药现代化研究"重点专项2019年度项目的若干认知,引入新兴的"材料化学工程"理念,提出"基于膜过程的中药绿色制造工程设计"的理论框架:针对实际应用体系的性质和需求,以实现高通量和高分离因子的统一为目标,根据中药物料复杂体系的化学多元性和药效物质整体观,建立中药水提液"溶液环境"检测技术,基于安全性、有效性对膜技术进行系统考察,开展膜过程优化、工艺集成等工艺设计。在多尺度范围内,特别是在介观尺度揭示中药物料与膜分离介质的"结构、性能与制备"的关系,并对过程设计、生产加工的流程进行模拟,构建中药绿色制造工程的理论基础。致力解决制约我国中药制药工业可持续发展的能源、资源和环境等瓶颈问题,构建中药制药学与材料化学工程交叉研究的学科新生长点。The implementation of membrane technology in the manufacturing of Chinese materia medica(CMM) plays a critical role in the strategic plan and demand from the perspective of national science and technology, and it is a new and high technology that needs to be popularized in Chinese medicine pharmaceutical industry. The manufacturing technology of CMM is primarily based on the theory and practices of chemical engineering in which the upgrade of its separation technology mainly relies on the advancement in chemical engineering. Our authors have been exploring and implementing membrane technology in the green manufacturing process of CMM in the past decade. Recently, we were granted funding in the topic of "The Modernization of Traditional Chinese Medicine" from The National Key Research and Development Program of China. In the research proposal, we introduced the emerging concept of "material-chemistry engineering", and suggested the concept of theoretical framework for "the process design and engineering of membrane-based green manufacturing of CMM". The framework included the establishment of analytical testing approach for precise analysis in aqueous CMM environment, a systematic testing and inspection method for the membrane and membrane process to guarantee the safety and effectiveness of the CMM products, as well as the integrated membrane process design and optimization for the CMM manufacturing process. The ultimate goal of the proposal is to achieve high flux and decent separation efficiency for CMM production in multi-scale range, in particular to understand the correlation between the aqueous CMM environment and the structure, property and preparation of the membrane. Furthermore, with the aid of computational modeling in process design and manufacturing, the theoretical foundation of membrane-based CMM green manufacturing can be assured. The innovation in the interdisciplinary of CMM production and material-chemistry engineering will help overcoming the current bottleneck encountered in the CMM manufactu

关 键 词：中药绿色制造 膜科技 材料化学工程 分离 多尺度 

分 类 号：R284[医药卫生—中药学]