β-榄香烯衍生化中的中间体合成的研究进展  

Research progress on synthesis of intermediates in derivatization of β-elemene

作　　者：惠子 李震 高园 蒋松伟 戚香 叶向阳 谢恬[1,3] HUI Zi;LI Zhen;GAO Yuan;JIANG Song-wei;QI Xiang;YE Xiang-yang;XIE Tian(College of Pharmacy,School of Medicine,Key Laboratory of Elemene Anti-cancer Chinese Medicine of Zhejiang Province,Engineering Laboratory of Development and Application of Traditional Chinese Medicine from Zhejiang Province,Hangzhou Normal University,Hangzhou 311121,China;School of Clinical Medicine,Guangdong Pharmaceutical University,Guangzhou 510000,China;Collaborative Innovation Center of Traditional Chinese Medicines from Zhejiang Province,Hangzhou 311121,China)

机构地区：[1]杭州师范大学医学院药学院,浙江省榄香烯类抗癌中药重点实验室,浙产中药材资源开发与应用浙江省工程实验室,浙江杭州311121 [2]广东药科大学临床医学院,广东广州510000 [3]浙八味等浙产中药材综合利用开发协同创新中心,浙江杭州311121

出　　处：《中草药》2020年第17期4547-4558,共12页Chinese Traditional and Herbal Drugs

基　　金：国家自然科学基金重点项目(81730108和81973635);杭州师范大学卓越人才计划科研启动基金资助项目(4125C5021920419)。

摘　　要：β-榄香烯是广谱抗肿瘤植物药榄香烯原料药的主要活性成分,也是榄香烯4种异构体中主要的异构体。侧重对β-榄香烯的衍生化过程中的关键中间体的合成进行归纳和总结,列举出它们的合成方法、反应具体条件、产物收率以及表征数据等。旨在通过总结,方便了解和掌握迄今为止这些中间体最优化的合成技术,启发对现有合成技术的进一步改进,激发对相关类型化合物衍生化的新思路和想法。β-Elemene is the main active ingredient of elemene, a broad-spectrum anti-cancer botanical drug, which is also the main isomer of elemene’s four isomers. The synthesis of some key intermediates were generalized and summarized during the derivatization of β-elemene, wherein the preparation methods, reaction conditions, yields, characterization data of these intermediates were listed. The purpose of this paper is to facilitate people in understanding and grasping the most optimal synthesis of these intermediates up to date, to inspire people pursuing further synthesis improvement, and to stimulate generation of new ideas for future derivatization of β-elemene.

关 键 词：Β-榄香烯 衍生化 中间体 合成 

分 类 号：R284.3[医药卫生—中药学]