Onset of Coronary Heart Disease is Associated with HCMV Infection and Increased CD14^+CD16^+Monocytes in a Population of Weifang,China  

作　　者：LI Hong Zheng WANG Qin ZHANG Yi Yuan WANG Jin Dong WU Hong Juan ZHANG Mo Gen LI Ji Chen LIU Zhi Jun 

机构地区：[1]Department of Medical Microbiology,Weifang Medical University,Weifang 261053,Shandong,China [2]National Institute for Viral Diseases Control and Prevention,China Center for Disease Control and Prevention,Beijing 102206,China [3]School of Clinical Medicine,Weifang Medical University,Weifang 261053,Shandong,China [4]Morphological Laboratory,Weifang Medical University,Weifang 261053,Shandong,China

出　　处：《Biomedical and Environmental Sciences》2020年第8期573-582,共10页生物医学与环境科学（英文版）

基　　金：Funded by the National Natural Science Foundation of China[81471048];the Natural Science Foundation of Shandong Province[ZR2019MC059];Shandong Province Government-Sponsored Overseas Study Project.&These authors contributed equally to this work.

摘　　要：Objective To investigate the relationship between human cytomegalovirus(HCMV)infection and peripheral blood CD14+CD16+monocytes in the pathogenesis of coronary heart disease(CHD),and to elucidate the mechanism of pathogenesis in CHD by analyzing the correlation between infection,inflammation,and CHD,to provide a basis for the prevention,evaluation,and treatment of the disease.Methods In total,192 patients with CHD were divided into three groups:latent CHD,angina pectoris,and myocardial infarction.HCMV-IgM and-IgG antibodies were assessed using ELISA;CD14+CD16+monocytes were counted using a five-type automated hematology analyzer;mononuclear cells were assessed using fluorescence-activated cell sorting;and an automatic biochemical analyzer was used to measure the levels of triglyceride,cholesterol,high-and low-density lipoprotein cholesterols,lipoprotein,hs-CRp and Hcy.Results The positive rates of HCMV-IgM and-IgG were significantly higher in the CHD groups than in the control group.HCMV infection affects lipid metabolism to promote immune and inflammatory responses.Conclusion HCMV infection has a specific correlation with the occurrence and development of CHD.The expression of CD14+CD16+mononuclear cells in the CHD group was increased accordingly and correlated with acute HCMV infection.Thus,HCMV antibody as well as peripheral blood CD14+CD16+mononuclear cells can be used to monitor the occurrence and development of CHD.

关 键 词：Human cytomegalovirus Coronary heart disease ANTIBODY CD14+CD16+monocytes Weifang 

分 类 号：R541.4[医药卫生—心血管疾病]