白介素-5和白介素-13血清水平与不同肥胖表型的关联分析  

Association of serum interleukin-5 and interleukin-13 levels with different obesity phenotypes

作　　者：柳宁 庄思琪[1] 付瑶阳 唐玲丽 唐浩能[1] LIU Ning;ZHUANG Si-qi;FU Yao-yang;TANG Ling-li;TANG Hao-neng(The Second Xiangya Hospital,Central South University,Changsha,Hunan 410011,China;School of Medicine,Yueyang Vocational and Technical College,Yueyang,Hunan 414000,China)

机构地区：[1]中南大学湘雅二医院,湖南长沙410011 [2]岳阳职业技术学院医学院,湖南岳阳414000

出　　处：《实用预防医学》2020年第10期1176-1181,共6页Practical Preventive Medicine

基　　金：国家自然科学基金(81600666)。

摘　　要：目的探究白介素-5(interleukin-5,IL-5)和白介素-13(interleukin-13,IL-13)血清水平与不同肥胖表型的关联,为肥胖及相关代谢性疾病的防控提供新思路。方法2018年11月—2019年4月在中南大学湘雅二医院进行健康体检的人群中选择肥胖人群,基于代谢异常情况分为代谢异常型肥胖(metabolically unhealthy obesity,MUO)组和代谢健康型肥胖(metabolically healthy obesity,MHO)组(每组72人),同期选取体重及代谢正常并与肥胖人群进行性别、年龄匹配的体检人群73人设为健康对照(healthy control,HC)组;检测IL-5和IL-13血清水平,通过logistic回归分析两种细胞因子与不同肥胖表型的关联,通过逐步线性回归分析两种细胞因子的主要影响因素。结果IL-13的MHO组和HC组间的比较有统计学意义(P<0.05),IL-5的MHO组和HC组间的比较无统计学意义。MUO组的IL-5和IL-13的血清水平升高明显,与MHO组和HC组相比差异均有统计学意义(P<0.05)。IL-5和IL-13血清水平与MHO表型的发生未存在显著关联,但均与MUO表型的发生存在显著的正向关联:IL-5每升高2 pg/ml,MUO表型发生的优势比增加81%(OR=1.81,95%CI:1.40~2.35,P<0.001),IL-13每升高10 pg/ml,MUO表型发生的优势比增加5%(OR=1.05,95%CI:1.03~1.07,P<0.001);多元线性逐步回归分析显示收缩压(systolic blood pressure,SBP)(β=0.296,P=0.000)和空腹血糖(fasting plasma glucose,FPG)(β=0.217,P=0.008)是IL-5水平的独立影响因素,腰围(waist circumference,WC)(β=0.186,P=0.018)和尿酸(uric acid,UA)(β=0.200,P=0.019)是IL-13的独立影响因素。结论IL-5与IL-13与代谢健康型肥胖表型无显著相关,与代谢异常型肥胖表型具有显著正向关联,两种细胞因子可能在肥胖的发生发展进程中具有不同的作用。Objective To explore the relationship of serum interleukin-5(IL-5)and interleukin-13(IL-13)levels with different obesity phenotypes so as to provide new ideas for prevention and control of obesity and related metabolic diseases.Methods The obese were selected from people underwent physical examination in the Second Xiangya Hospital of Central South University from November 2018 to April 2019,and all of them were divided into the metabolically unhealthy obesity(MUO)group and the metabolically healthy obesity(MHO)group(each n=72)according to the abnormality of metabolism.During the same period,73 persons who had normal body weight and metabolism and were gender-and age-matched with the obese were selected as the healthy control(HC)group.The serum levels of IL-5 and IL-13 were measured.The logistic regression was used to analyze the association of the two cytokines with different obese phenotypes,and the stepwise linear regression analysis was performed to identify the main factors influencing the two cytokines.Results There was a statistically significant difference in the comparison of IL-13 between the MHO group and the HC group(P<0.05),but no statistically significant difference was found in the comparison of IL-5 between the two groups.The serum levels of IL-5 and IL-13 in the MUO group increased significantly,showing statistically significant differences as compared with the MHO group and the HC group(both P<0.05).Serum IL-5 and IL-13 levels were not significantly correlated with MHO phenotype,but significantly and positively correlated with MUO phenotype.Every time IL-5 increased 2 pg/ml,the odds ratio of MUO phenotype increased by 81%(OR=1.81,95%CI:1.40-2.35,P<0.0001).Every time IL-13 increased 10 pg/ml,the odds ratio of MUO phenotype increases by 5%(OR=1.05,95%CI:1.03-1.07,P<0.0001).Multiple linear stepwise regression analysis showed that systolic blood pressure(β=0.296,P=0.000)and fasting plasma glucose(β=0.217,P=0.008)were the independent factors influencing the level of IL-5,while waist circumference(�

关 键 词：肥胖表型 代谢异常型肥胖 代谢健康型肥胖 细胞因子 白介素-5 白介素-13 

分 类 号：R589.2[医药卫生—内分泌]