重庆市1~ 30岁健康人群麻疹、风疹病毒抗体水平调查  

Antibody levels of measles and rubella among healthy population aged 1-30 years in Chongqing municipality

作　　者：刘洋[1] 吴芸芸 王青[1] LIU Yang;WU Yun-yun;WANG Qing(Chongqing Center for Disease Control and Prevention,Chongqing 400042,China)

机构地区：[1]重庆市疾病预防控制中心,重庆400042

出　　处：《实用预防医学》2020年第10期1220-1222,共3页Practical Preventive Medicine

摘　　要：目的了解重庆市健康人群麻疹、风疹病毒抗体水平,为制定免疫策略提供依据。方法2018年10月,采用多阶段整群随机抽样的方法,抽取8个监测区县,每个监测区县抽取2个监测点(村委会或社区),各监测点随机抽取1~30岁人群188人采集血标本并开展问卷调查。采用ELISA检测麻疹、风疹病毒IgG抗体水平。结果共采集了2855人份血样,麻疹病毒IgG抗体阳性率为93.42%,风疹病毒IgG抗体阳性率为88.65%。麻疹病毒IgG抗体阳性率在不同年龄组(χ2=121.873,P<0.05)、不同地区(χ2=31.703,P<0.05)间差异有统计学意义;在不同性别(χ2=0.204,P>0.05)、不同民族(χ2=3.782,P>0.05)间差异无统计学意义。风疹病毒IgG抗体阳性率在不同年龄组(χ2=54.858,P<0.05)、不同地区(χ2=99.009,P<0.05)、不同民族(χ2=11.331,P<0.05)间差异有统计学意义;在不同性别(χ2=0.255,P>0.05)间差异无统计学意义。7~14岁人群中麻疹、风疹病毒IgG抗体阳性率均较低,渝北区、垫江县抗体阳性率较低。结论重庆市健康人群中,麻疹、风疹病毒IgG抗体水平总体较高,但仍存在薄弱环节。需针对重点年龄组和薄弱地区适时开展含麻疹风疹成分疫苗补充免疫,减少易感人群。Objective To understand the antibody levels of measles and rubella among healthy population in Chongqing municipality so as to provide a basis for formulating immunization strategies.Methods A multistage cluster random sampling method was used to select 8 monitored districts/counties in Chongqing municipality in October,2018,and then 2 monitored sites(village committee or community)were selected from each monitored district/county.188 residents aged 1-30 years were randomly chosen from each monitored sites to conduct blood sampling and questionnaire surveys.Enzyme-linked immune-sorbent assay was employed to detect the serum levels of measles and rubella immunoglobulin G(IgG)antibodies.Results A total of 2,855 blood specimens were collected,and the positive rates of measles and rubella IgG antibodies were 93.42%and 88.65%,respectively.The positive rate of measles IgG antibody showed statistically significant differences among different age groups(χ2=121.873,P<0.05)and different monitored districts/counties(χ2=31.703,P<0.05),but showed no statistically significant differences between different genders(χ2=0.204,P>0.05)as well as among different ethnic groups(χ2=3.782,P>0.05).The positive rate of rubella IgG antibody showed statistically significant differences among different age groups(χ2=54.858,P<0.05),different monitored districts/counties(χ2=99.009,P<0.05)and different ethnic groups(χ2=11.331,P<0.05),but showed no statistically significant difference in different genders(χ2=0.255,P>0.05).The positive rates of measles and rubella IgG antibodies were lower in the age group of 7-14 years as well as in some areas like Yubei district and Dianjiang county.Conclusions The serum levels of measles and rubella IgG antibodies were generally high among healthy population in Chongqing municipality,but the low positive rates were still found in the age group of 7-14 years and some areas.Strategies like using the measles-rubella vaccine in a catch-up campaign should be conducted in time in those priority areas and age

关 键 词：麻疹 风疹 抗体水平 健康人群 

分 类 号：R186[医药卫生—流行病学]