血小板参与动脉粥样硬化斑块形成的分子途径  

The Molecular Mechanism of Platelets in Atherosclerotic Plaque Formation

作　　者：唐朝君 王蕾[1,2,3] 朱力 TANG Chao-jun;WANG Lei;ZHU Li(Cyrus Tang Hematology Center,Cyrus Tang Medical Institute,Soochow University,Suzhou,215123;Suzhou Key Laboratory of Thrombus and Vascular Disease,Suzhou,215123;Collaborative Intwvation Center of Hematology of Jiangsu Province,Suzhou,215123,China)

机构地区：[1]苏州大学唐仲英医学研究院唐仲英血液学研究中心,苏州市215123 [2]苏州市血栓与血管生物学重点实验室,苏州市215123 [3]江苏省血液学协同创新中心,苏州市215123

出　　处：《中国分子心脏病学杂志》2020年第4期3437-3444,共8页Molecular Cardiology of China

摘　　要：血小板在血栓形成,血液凝固,维持血管稳态及修复血管损伤等生理病理过程中起重要作用。近年来研究发现血小板也可作为炎症细胞参与机体宿主防御,发挥免疫功能。动脉粥样硬化是一种慢性血管炎症性疾病,在血管炎症发生过程中,血小板可通过表面受体或释放储存在血小板颗粒中的分子促进血小板与炎症细胞(如血管内皮细胞、平滑肌细胞、单核细胞)相互作用,从而参与动脉粥样硬化发生。本文主要围绕血小板参与动脉粥样硬化斑块形成的途径,及其作为动脉粥样硬化早期防治靶点的最新进展进行综述。Platelets play an important role in the physiological and pathological processes including thrombosis,coagulation,vascular homeostasis,and repairing.In recent years,accumulated evidence revealed that platelets could act as inflammatory cells participating in the host defense and inducing immune response.Atherosclerosis is a chronic vascular inflammatory disease.During vascular inflammation,platelets interact with inflammatory cells(such as vascular endothelial cells,smooth muscle cells,monocytes)through surface receptors or cytokines stored in platelet dense orαgranules participating in the atherogenesis.This review focuses on the molecular pathways of platelets in the formation of atherosclerotic plaque and their latest progress in targeted therapy for atherosclerosis treatment.

关 键 词：血小板 动脉粥样硬化 血管炎症 分子靶标 

分 类 号：R543.5[医药卫生—心血管疾病]