聚多巴胺涂层聚丙烯疝气补片的制备及其体外炎性反应  

Preparation and in vitro inflammation evaluation of polydopamine coated polypropylene hernia mesh

作　　者：乔燕莎 王茜[1,2] 李彦 桑佳雯 王璐[1,2,3] QIAO Yansha;WANG Qian;LI Yan;SANG Jiawen;WANG Lu(College of Textiles, Donghua University, Shanghai 201620, China;Key Laboratory of Textile Science & Technology of Ministry of Education, Donghua University, Shanghai 201620, China;Key Laboratory of Textile Industry for Biomedical Textile Materials and Technology, Donghua University, Shanghai 201620, China)

机构地区：[1]东华大学纺织学院,上海201620 [2]东华大学纺织面料技术教育部重点实验室,上海201620 [3]东华大学纺织行业生物医用纺织材料与技术重点实验室,上海201620

出　　处：《纺织学报》2020年第9期162-166,共5页Journal of Textile Research

基　　金：国家重点研发计划专项资助项目(2016YFB0303300);教育部创新引智基地111计划项目(B07024);中央高校基本科研业务费专项资金、东华大学研究生创新基金项目(CUSF-DH-D-2020018);上海市大学生创新项目(101-03-0178239)。

摘　　要：为降低聚丙烯(PP)补片的炎性反应,利用多巴胺氧化自聚合,在PP单丝表面制备了聚多巴胺(PDA)抑炎涂层,并对PDA-PP补片的微观形貌、表面成分、接触角、涂层稳定性、力学性能、体外抗氧化和体外抗炎性能进行了表征与分析。结果表明:PDA可在PP单丝表面形成分布均匀的微纳米颗粒涂层,进而使得PP表面的理化性能呈现出相应的变化;PDA不影响PP补片的力学性能,且抗氧化能力和形貌稳定性均可满足炎性反应初期调控的需求;通过炎性应答标志TNF-α和IL-6的24 h释放量可知,黏附于PDA-PP的巨噬细胞较PP补片分别降低了93%和100%的释放,初步证实PDA涂层可有效降低PP补片的体外炎性反应,进而有望应用于临床评估研究。To reduce the possibility of inflammation with the use of polypropylene(PP)hernia mesh,dopamine was oxidized and self-polymerized for the preparation of an anti-inflammatory polydopamine(PDA)coating on the surface of PP monofilament.The micro-morphology,surface composition,water contact angle,coating stability,mechanical property,in vitro anti-oxidant and anti-inflammatory properties of PDA-PP were characterized and analyzed.The results show that PDA formed a coating of micro-nano particles with uniform distribution on PP fiber surfaces,and the coating changed physicochemical properties of PP mesh.Meanwhile,the original mechanical property of PP mesh is not affected by the PDA coating,and the antioxidant ability and good stability of the PDA coated PP mesh meet the needs of the initial inflammatory regulation.The protein expression level of the inflammation marker TNF-αand IL-6 at 24 h indicate a 93%and 100%lower expression levels for macrophages adhered PDA-PP mesh than that of the PP mesh,respectively.The PDA-PP mesh is expected for clinical evaluation studies next.

关 键 词：医用纺织品 聚丙烯补片 炎性反应 聚多巴胺 抗氧化剂 抗炎 

分 类 号：TS181.8[轻工技术与工程—纺织材料与纺织品设计]