基于R-Shiny实现临床试验信息检索及Meta分析的工具开发——以非小细胞肺癌为例  

Development of tools for clinical trial information retrieval and Meta-analysis based on R-Shiny:Taking non-small cell lung cancer as an example

作　　者：于朝雷 柏建岭[1] 于浩[1] 赵杨[1] YU Zhaolei;BAI Jianling;YU Hao;ZHAO Yang(School of Public Health Nanjing Medical University,Nanjing 211166,Jiangsu,China)

机构地区：[1]南京医科大学公共卫生学院,江苏南京211166

出　　处：《中国临床药理学与治疗学》2020年第9期984-991,共8页Chinese Journal of Clinical Pharmacology and Therapeutics

基　　金：国家自然科学基金(81872709);江苏省青蓝工程学科带头人计划;南京医科大学中青年教师支持计划。

摘　　要：目的:开发出一个能够提供图形用户界面(graphical user interface,GUI)的临床试验文章数据检索和Meta分析整合的工具。方法:使用R语言Shiny包开发并构建基于Bootstrap框架的Web应用,并基于DT、Meta、gemtc等R包完成数据检索和Meta分析功能的实现。结果:软件可以根据用户需求进行文章和变量的筛选,信息以表格形式呈现。用户也可以选择不同的试验组药物和对照组药物来进行经典Meta分析,增加或者减去不同的研究来构建药物之间的网络图进行网状Meta分析。结论:此工具界面友好、操作方便,绘图及分析结果准确,能够为研究者带来便利。AIM:To develop a tool providing the graphical user interface(GUI),which can integrate Meta-analysis and information retrieval from clinical trials.METHODS:The Web application based on the Bootstrap framework was built with the Shiny package of R language,and the information retrieval and meta-analysis functions were implemented based on the R packages of DT,Meta,gemtc,etc.RESULTS:The tool could filter the articles and variables according to the user's requirements,and the information presented in the form of a table.Users can also select different experimental group drugs and control group drugs for classic meta-analysis,and add or subtract different studies to construct the network map between drugs for network meta-analysis.CONCLUSION:This tool has a friendly user interface,which is easy to use,accurate in analysis and drawing results,and can bring convenience to researchers.

关 键 词：临床试验 META分析 Shiny框架 

分 类 号：R969[医药卫生—药理学]