TenascinC、H-FABP、NT-proBNP的变化与瓣膜性心脏病心力衰竭患者心功能变化的关系  

The correlation between the changes of Tenascin C,H-FABP,NT-proBNP and cardiac function in patients with valvular heart disease complicated by heart failure

作　　者：杜永海 霍玉峰 DU Yonghai;HUO Yufeng(Dpartment of Cardial Surgery,Qingdao Branch of Qilu Hospital, Shandong, Qingdao 266000,China)

机构地区：[1]山东大学齐鲁医院青岛院区心外科,山东省青岛市266000

出　　处：《河北医药》2020年第19期2975-2977,共3页Hebei Medical Journal

摘　　要：目的探讨血清腱糖蛋白C(TenascinC)、心型脂肪酸结合蛋白(H-FABP)、氨基末端脑钠肽前体(NT-proBNP)的变化与瓣膜性心脏病心力衰竭心功能变化的关系。方法选取确诊的风湿性心脏病慢性心力衰竭患者92例为病例组,另选同期健康体检对象60例为对照组,检测2组的TenascinC、H-FABP、NT-proBNP水平、左心室舒张末期内径(LVEDD)、左心室射血分数(LVEF%)、左心室收缩末期内径(LVESD),并按照纽约心脏病分级(NYHA)对病例组进行分组分析;采用简单线性相关分析法分析TenascinC、H-FABP、NT-proBNP水平与LVEF%的相关性。结果2组TenascinC、H-FABP、NT-proBNP水平比较分析,病例组均高于对照组(P<0.05);病例组的LVEDD、LVESD值高于对照组,差异有统计学意义(P<0.05);病例组的LVEF%值低于对照组,差异有统计学意义(P<0.05);NYHA分级为Ⅱ级、Ⅲ级、Ⅳ级的风湿性心脏病慢性心力衰竭患者TenascinC、H-FABP、NT-proBNP水平逐渐升高,组间比较差异均有统计学意义(P<0.05);风湿性心脏病慢性心力衰竭患者TenascinC、H-FABP、NT-proBNP水平与LVEF%呈显著的负相关关系(P<0.05)。结论瓣膜性心脏病心力衰竭患者血清TenascinC、H-FABP、NT-proBNP水平显著升高,并且与心功能损害程度具有重要的关系。Objective To investigate the correlation between the changes of serum tenascin C,heart-type fatty acid binding protein(H-FABP),amino-terminal brain natriuretic peptide precursor(NT-proBNP)and heart function in patients with heart failure due to valvular heart disease.Methods Ninety-two patients with rheumatic heart disease complicated by chronic heart failure(case group)and 60 healthy subjects(control group)were enrolled in the study.The levels of Tenascin C,H-FABP,NT-proBNP,left ventricular ejection fraction(LVEF%),left ventricular end-diastolic diameter(LVEDD),left ventricular end-systolic diameter(LVESD)were detected in both groups.Moreover the grouping analysis was performed in case group according to New York Heart Disease Classification(NYHA).And the simple linear correlation analysis was used to analyze the correlation between Tenascin C,H-FABP,NT-proBNP and LVEF%.Results The levels of Tenascin C,H-FABP and NT-proBNP in case group were significantly higher than those in control group(P<0.05),and the levels of LVEDD and LVESD in case group were significantly higher than those in control group(P<0.05),however,the LVEF%levels incase group were significantly lower than those in control group(P<0.05).The levels of Tenascin C,H-FABP,NT-proBNP were gradually increased with the increasing of NYHA grade(gradeⅡ,gradeⅢ,gradeⅣ)(P<0.05).In addition the levels of Tenascin C,H-FABP,NT-proBNP in patients with rheumatic heart disease complicated by heart failure were closely negatively correlated with those of LVEF%(P<0.05).Conclusion The serum levels of Tenascin C,H-FABP and NT-proBNP in patients with valvular heart disease complicated by heart failure are significantly increased,which are closely correlated with the severity of cardiac function damage.

关 键 词：腱糖蛋白C 心型脂肪酸结合蛋白 氨基末端脑钠肽前体 瓣膜性心脏病 心力衰竭 心功能 

分 类 号：R542.5[医药卫生—心血管疾病]