手性钌螯合催化剂的合成及在α⁃羟基酯的动态动力学氢化反应中的应用  

Synthesis and Application of Chiral Ru Pincer Catalysts on the Hydrogenation ofα-Hydroxy Esters by Dynamic Kinetic Resolution

作　　者：汪贲文 杜甜 汤卫军 WANG Biwen;DU Tian;TANG Weijun(School of Chemistry&Chemical Engineering,Shaanxi Normal University,Xi’an710119,China;Experimental Chemistry Center of Lanzhou Jiaotong University,Lanzhou730070,China)

机构地区：[1]陕西师范大学化学化工学院,西安710119 [2]兰州交通大学实验管理中心,兰州730070

出　　处：《高等学校化学学报》2020年第10期2256-2263,M0004,共9页Chemical Journal of Chinese Universities

基　　金：国家自然科学基金(批准号:21672133)资助.

摘　　要：设计并合成了一系列基于(R)-2-(二苯基膦基)-1-苯基-N-(2′-吡啶甲基)-1-乙胺及其衍生物的手性钌螯合催化剂.采用核磁共振波谱及高分辨质谱对其进行表征,并给出单晶结构.以α-羟基酯类化合物为研究对象,通过酯的动态动力学氢化还原反应,发展了一种合成手性二醇的方法.研究结果表明,该催化体系能有效实现酯的氢化还原,并获得一定的对映选择性.A series of chiral Ru catalysts based on(R)-2-(diphenylphosphanyl)-1-phenyl-N-(pyridin-2-yl⁃methyl)ethan-1-amine and its derivatives were designed and synthesized.The catalysts were characterized by nuclear magnetic resonance spectrometer and high resolution mass spectrometry.The structure was confirmed by X-ray crystallographic analysis.Withα-hydroxy ester compounds as the substrates,the synthesis of chiral diols was developed by dynamic kinetic resolution under the conditions of hydrogenation.The catalytic system can be applied to the hydrogenation ofα-hydroxyester,giving the corresponding product in good enantioselec⁃tivities.

关 键 词：氢化 动态动力学拆分 α-羟基酯 钌鳌合催化剂 手性二醇 

分 类 号：O622[理学—有机化学]