钌催化的手性苯基/苯并噻唑甲醇的转移氢化合成  

Synthesis of Chiral Phenylbenzothiazole Methanol via Transfer Hydrogenation Catalyzed by Ruthenium Complexes

作　　者：陈淡宜 张福梅 何丹 张紫媚 钟芬 文思妙妙 刘祈星 周海峰 CHEN Danyi;ZHANG Fumei;HE Dan;ZHANG Zimei;ZHONG Fen;WEN Simiaomiao;LIU Qixing;ZHOU Haifeng(Hubei Key Laboratory of Natural Products Research&Development,College of Biological&Pharmaceutical Sciences,China Three Gorges University,Yichang 443002,China)

机构地区：[1]三峡大学生物与制药学院,天然产物研究与利用湖北省重点实验室,宜昌443002

出　　处：《高等学校化学学报》2020年第10期2264-2271,M0004,共9页Chemical Journal of Chinese Universities

基　　金：湖北省自然科学基金(批准号:2018CFB241)资助.

摘　　要：以苯基/苯并噻唑甲酮为原料,手性二胺钌络合物为催化剂,甲酸钠为氢源,i⁃PrOH/H2O(体积比1:1)为溶剂,在室温(30℃)条件下,通过不对称转移氢化,合成了一系列手性苯基/苯并噻唑甲醇类化合物,其对映选择性(e.e.)值高达99%.此外,还探讨了其它苯基/氮杂环甲酮的不对称转移氢化.该方法具有反应条件温和、催化剂廉价易得及操作简便等优点.A series of chiral phenylbenzothiazole methanol was obtained with up to 99%e.e.value via transfer hydrogenation from phenylbenzothiazolone,with readily available chiral diamine-derived ruthenium complex as a catalyst and sodium formate as a hydrogen source in a mixture of i-PrOH/H2O(volume ratio 1:1)under ambient conditions.In addition,the reduction of other aryl N-heteroaryl ketones was also attempted.This method has the advantages of mild rection conditions,readily available and inexpensive catalysts,simple operation.

关 键 词：不对称转移氢化 手性二胺钌络合物 苯基/苯并噻唑甲醇 

分 类 号：O626.25[理学—有机化学]