容积旋转调强放疗与静态调强放疗对胸腔胃放射性损伤的影响比较  

Effect comparison of volumetric modulated arc therapy and intensity modulation radiotherapy on the radiation-induced injury of thoracic gastric

作　　者：沈健 王高仁 邰国梅[1] SHEN Jian;WANG Gaoren;TAI Guomei(Department of Radiotherapy,Nantong Tumor Hospital,Jiangsu Province,Nantong 226361)

机构地区：[1]江苏省南通市肿瘤医院放疗科,南通226361

出　　处：《南通大学学报（医学版）》2020年第4期326-328,共3页Journal of Nantong University(Medical sciences)

基　　金：南通市科技指导计划项目(GJZ16093)。

摘　　要：目的:比较容积旋转调强放疗(volumetric modulated arc therapy,VMAT)及静态调强放疗(intensity modulation radiotherapy,IMRT)对食管癌术后纵隔淋巴结转移患者胸腔胃放射性损伤的影响。方法:将38例食管癌根治术后纵隔淋巴结转移患者随机分为两组,每组19例。观察组予以VMAT,对照组予以IMRT。记录患者放疗前、中、后的症状、体征,体质量指数(body mass index,BMI)、血清前白蛋白、血清白蛋白、血清总蛋白、血红蛋白。观察比较患者自放疗开始至胸腔胃放射性损伤症状出现的时间及程度。结果:观察组胸腔胃放射性损伤中位发生时间为20.47 d,对照组为13.79 d;观察组胸腔胃放射性损伤程度较对照组明显减低(P=0.041);患者BMI、血清前白蛋白、血清白蛋白、血清总蛋白、血红蛋白在观察组治疗前后无明显变化,而对照组治疗后较治疗前显著下降(P<0.05)。结论:VMAT能明显有效延缓胸腔胃放射性损伤发生时间,减轻胸腔胃放射性损伤的程度,从而可改善患者的营养状况。Objective:To investigate the effect of volumetric modulated arc therapy(VMAT)and intensity modulation radiotherapy(IMRT)on the radiation-induced injury of thoracic gastric in patients with mediastinal lymph node metastasis after esophageal carcinoma after surgery.Methods:38 patients with mediastinal lymph node metastasis after radical resection of esophageal carcinoma were randomly divided into two groups.The observation group was given VMAT radiotherapy,and the control group was given IMRT.The symptoms,signs,body mass index(BMI),serum prealbumin,serum albumin,serum total protein,and hemoglobin were recorded before and after radiotherapy.Results:The median time of the radiation-induced injury about thoracic gastric was 20.47 days in the observation group and 13.79 days in the control group.The degree of the radiation-induced injury about thoracic gastric in the observation group was significantly lower than that in the control group(P=0.041).There was no significant change in BMI,serum prealbumin,serum albumin,serum total protein and hemoglobin between before and after treatment in the observation group,while the control group showed a significant decrease after treatment(P<0.05).Conclusions:VMAT can effectively delay the occurrence of the radiation-induced injury of thoracic gastric and reduce the degree of the radiation-induced injury of thoracic gastric,thus improving the nutritional status of patients.

关 键 词：容积旋转调强 静态调强放疗 食管癌术后纵隔淋巴结转移 胸腔胃放射性损伤 营养状况 

分 类 号：R815[医药卫生—放射医学]