持续不卧床腹膜透析患者血清可溶性Klotho、FGF-23水平与颈动脉钙化的相关性研究  

Correlation of serum soluble Klotho and FGF-23 with carotid artery calcification in patients undergoing continuous ambulatory peritoneal dialysis

作　　者：郭乃凤[1] 曹赟 王熙坚 吴建华[1] 陈晓岚[1] 戴厚永[1] GUO Naifeng;CAO Yun;WANG Xijian;WU Jianhua;CHEN Xiaolan;DAI Houyong(Department of Nephrology,the Affiliated Hospital of Nantong University,Nantong 226001)

机构地区：[1]南通大学附属医院肾内科,南通226001

出　　处：《南通大学学报（医学版）》2020年第4期336-338,共3页Journal of Nantong University(Medical sciences)

基　　金：南通市社会民生科技项目(MS12018045)。

摘　　要：目的:研究持续不卧床腹膜透析(continuous ambulatory peritoneal dialysis,CAPD)患者颈动脉钙化情况,分析血清可溶性Klotho蛋白、血清成纤维细胞生长因子23(fibroblast growth factor 23,FGF-23)与颈动脉钙化发生的相关性。方法:选取73例CAPD患者为研究对象,根据彩超检查结果分成颈动脉钙化组与非颈动脉钙化组,比较两组基本指标并采用Logistic回归分析引起颈动脉钙化的影响因素。结果:73例CAPD患者中颈动脉钙化40例(54.8%);单因素回归分析显示颈动脉钙化组与非颈动脉钙化组在年龄、透析时间、Klotho蛋白、FGF-23上存在差异,而多因素分析显示年龄与FGF-23的增加及Klotho的减少为引起颈动脉钙化的独立危险因素。结论:CAPD患者年龄、血清FGF-23和Klotho水平与其颈动脉钙化密切相关。Objective:To investigate the status of carotid artery calcification in patients undergoing continuous ambulatory peritoneal dialysis(CAPD),and to analyze the relationship between serum soluble Klotho protein and fibroblast growth factor 23(FGF-23)and the occurrence of carotid artery calcification.Methods:73 peritoneal dialysis patients were enrolled and divided into the carotid artery calcification group and the non-carotid artery calcification group according to the results of color doppler ultrasound.The basic indicators of the two groups were compared and the influencing factors of carotid artery calcification were analyzed by Logistic regression.Results:Among the 73 CAPD patients,40 cases(54.8%)had carotid artery calcification.Univariate analysis showed significant differences in age,dialysis time,Klotho protein and FGF-23 between carotid artery calcification and non-carotid artery calcification group.Multivariate analysis showed that higher age and FGF-23,whereas lower Klotho were independent risk factors for carotid artery calcification in patients with CAPD.Conclusion:Age,serum FCF-23 and Klotho levels are closely related to carotid artery calcification in CAPD patients.

关 键 词：持续不卧床腹膜透析 KLOTHO蛋白 成纤维细胞生长因子23 颈动脉钙化 

分 类 号：R459.5[医药卫生—治疗学]