黄酮类化合物对肉鸡的免疫调节作用及其机制  

Immunomodulatory Effect of Flavonoids on Broilers and Its Mechanism

作　　者：杨硕[1] 金晓[1] 徐元庆[1] 史彬林[1] YANG Shuo;JIN Xiao;XU Yuanqing;SHI Binlin(College of Animal Science,Inner Mongolia Agricultural University,Hohhot 010018,China)

机构地区：[1]内蒙古农业大学动物科学学院,呼和浩特010018

出　　处：《动物营养学报》2020年第9期4003-4009,共7页CHINESE JOURNAL OF ANIMAL NUTRITION

基　　金：国家自然科学基金项目(31660674);研究生科研创新资助项目(B20191138Z)。

摘　　要：在自然界中黄酮类化合物广泛存在于多种植物中,而且作为主要的次生代谢产物之一表现出多种生物活性(抗病毒、抗炎、抗氧化等)。鉴于此,黄酮类化合物在畜禽生产中的应用引起相关研究人员的重视。本文就黄酮类化合物对肉鸡免疫器官、体液免疫、细胞免疫的影响及对免疫相关信号通路[核因子-κB(NF-κB)信号通路和核因子E2相关因子2(Nrf2)信号通路]的调控作用机制进行归纳总结,以期揭示黄酮类化合物对肉鸡的免疫调节机制,并为黄酮化合物作为饲料添加剂用于肉鸡养殖提供科学理论依据。In nature,flavonoids are widely found in a variety of plants,and as one of the main secondary metabolites,they exhibit a variety of biological activities(antiviral,anti-inflammatory,antioxidant,etc.).In view of this,the application of flavonoids in livestock and poultry production has attracted the attention of related researchers.This article summarized the effects of flavonoids on immune organs,humoral immunity,cellular immunity,and the regulatory mechanism on immune-related signaling pathways(nuclear factor-κB signaling pathway and nuclear factor E2 associated factor 2 signaling pathway)in broilers,in order to reveal the immunomodulatory mechanisms of flavonoids on broilers and provide a theoretical basis for the scientific application of flavonoids in broiler breeding.

关 键 词：黄酮类化合物 肉鸡 免疫 信号通路 

分 类 号：S816.7[农业科学—饲料科学]