端粒保护蛋白TRF2的研究进展  

Research progress of telomere protective protein TRF2

作　　者：张沛欣 张颖 ZHANG Pei-Xin;ZHANG Ying(Department of Infectious Diseases,the Second Affiliated Hospital of Air Force Medical University,Xi’an 710038,China)

机构地区：[1]空军军医大学第二附属医院传染科,西安710038

出　　处：《生命科学》2020年第7期717-722,共6页Chinese Bulletin of Life Sciences

基　　金：国家自然科学基金面上项目(81870414);国家科技重大专项(2018ZX10302-206);空军军医大学第二附属医院创新发展基金国际合作项目(2017GJHZ001)。

摘　　要：端粒是染色体末端的核蛋白结构。染色体末端重复的端粒DNA可以规避不适当的DNA损伤反应(DNA damage response,DDR)的激活,维持染色体的稳定性,端粒的缺失会引起染色体融合并导致细胞的衰老及死亡。端粒特异性蛋白复合物Shelterin在保护端粒完整性方面具有重要作用。在这个复合体中,端粒结合因子2(telomeric-repeat binding factor 2,TRF2)在维持端粒稳定、防止端粒染色体末端融合以及端粒染色体复制过程中发挥关键作用。该文综述了TRF2介导的保护染色体末端的多方面的机制。Telomeres are nucleoprotein structures capping the natural termini of chromosomes.The repetitive telomeric DNA at chromosome ends is protected from improper DNA damage response and maintain telomere stability.Loss of telomeres causes chromosome fusion and leads to cell senescence and death.Shelterin,a telomerespecific protein complex,plays an important role in protecting the integrity of telomeres.Within this complex,TRF2 has emerged as the key player in telomere genome instability,telomere end-to-end fusions and replicative damage.This review aims at exploring the complex and multifaceted mechanisms underlying the TRF2-mediated protection of chromosome ends.

关 键 词：端粒 端粒保护蛋白 端粒结合蛋白2 

分 类 号：Q243[生物学—细胞生物学]