退化蛋白/上皮钠通道超家族成员的激活与调控机制  

Research on the activation and regulation mechanisms of DEG/ENaC superfamily

作　　者：唐泽华 杨晓娜[1] 卢向阳[1] 牛友芽 田云[1] TANG Ze-Hua;YANG Xiao-Na;LU Xiang-Yang;NIU You-Ya;TIAN Yun(College of Bioscience and Biotechnology,Hunan Agricultural University,Changsha 410128,China;School of Medicine,Hunan University of Medicine,Huaihua 418000,China)

机构地区：[1]湖南农业大学生物科学技术学院,长沙410128 [2]湖南医药学院医学院,怀化418000

出　　处：《生命科学》2020年第7期723-730,共8页Chinese Bulletin of Life Sciences

基　　金：国家自然科学基金项目(31971042);湖南省自然科学基金杰出青年基金项目(2018JJ1012);湖南省科技厅项目(2018RS3086);湖南省教育厅重点项目(17A153);湖南省研究生科研创新项目(CX2015B240);怀化市科技计划项目(2018N2205)。

摘　　要：退化蛋白/上皮钠通道(DEG/ENaC)超家族是20世纪90年代发现的一类非电压依赖性的、阿米诺利敏感的钠离子选择性离子通道,其激活方式复杂多样,参与如囊肿性纤维化、焦虑及癫痫等多种生理病理过程,已成为多种疾病的潜在药物靶标。现就DEG/ENaC超家族成员的结构、特异激活方式以及交互激活与调控机制进行综述。Degenerin/epithelial sodium channel(DEG/ENaC)superfamily of ion channels consists of diverse members of non-voltage-gated,amiloride-sensitive,sodium-selective cation channels,and were found in the 1990s.DEG/ENaCs,with variable activation mechanisms,are involved in various physiological and pathological process,such as cystic fibrosis,anxiety and epilepsy,which makes them potential drug targets for various disease.Here,we summarize the knowledge of structure,the specific activation mechanisms,the interactive activation and regulation mechanisms of DEG/ENaCs.

关 键 词：退化蛋白/上皮钠通道超家族 离子通道 激活机制 小分子配体 

分 类 号：Q75[生物学—分子生物学]